Table 4 Associations between IFNL4-rs368234815 and IFNL3-rs4803217 with infections in 914 children from the Mali birth cohort study.

Infection		IFNL4-rs368234815^a		IFNL3-rs4803217^a		Models with both variants^c
		IFNL4-rs368234815^a		IFNL3-rs4803217^a		rs368234815		rs4803217
		OR, 95%CI	P val	OR, 95%CI	P val	OR, 95%CI	P val	OR, 95%CI	P val
Malaria^b	Never	Ref		Ref		Ref		Ref
	Any	1.30	0.033	1.19 (0.94–1.50)	0.15	1.73 (0.96–3.10)	0.068	0.74 (0.42–1.31)	0.30
	Any	(1.02–1.65)	0.033	1.19 (0.94–1.50)	0.15	1.73 (0.96–3.10)	0.068	0.74 (0.42–1.31)	0.30
	SM	1.48	0.061	1.52 (1.01–2.27)	0.044	1.04 (0.37–2.88)	0.94	1.46 (0.54–3.98)	0.45
	SM	(0.98–2.24)	0.061	1.52 (1.01–2.27)	0.044	1.04 (0.37–2.88)	0.94	1.46 (0.54–3.98)	0.45
	NSM	1.28	0.047	1.15 (0.91–1.46)	0.25	1.87 (1.03–3.38)	0.039	0.67 (0.37–1.19)	0.17
	NSM	(1.00–1.63)	0.047	1.15 (0.91–1.46)	0.25	1.87 (1.03–3.38)	0.039	0.67 (0.37–1.19)	0.17
GII	Never	Ref
	Ever	1.53	0.005	1.35 (1.00–1.82)	0.047	2.34 (1.06–5.19)	0.036	0.63 (0.29–1.39)	0.26
	Ever	(1.13–2.07)	0.005	1.35 (1.00–1.82)	0.047	2.34 (1.06–5.19)	0.036	0.63 (0.29–1.39)	0.26
RI	Never	Ref
RI	Ever	1.2 (0.63–2.28)	0.58	1.24 (0.66–2.33)	0.51	0.94 (0.23–3.90)	0.93	1.31 (0.32–5.31)	0.71

any malaria positivity by blood smear test with/without additional clinical symptoms; SM severe malaria; NSM non-severe malaria. $-additionally adjusting for tribes. In bold - significant associations.
^aLogistic regression analysis based on additive genetic models and adjusting for the duration of follow-up (weeks).
^bResults for malaria are adjusted for HBB status.
^cResults for models including both variants.

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