Fig. 3: Differentially Expressed (DE) gene clusters 2 and 3 distinguish CeD status. | Genes & Immunity

Fig. 3: Differentially Expressed (DE) gene clusters 2 and 3 distinguish CeD status.

From: Transcriptomics and eQTLs reveal inflammatory heterogeneity in the duodenal lining in coeliac disease

Fig. 3

A Singscores (y-axis) for clusters 2 and 3 (left), cluster 2 (centre), and cluster 3 (right), grouped by CeD condition (x-axis). Statistical analysis: Kruskal-Wallis and Dunn post-hoc tests. B ROC curves with AUC values for CeD condition classification using cluster-specific singscores. Comparisons: CTRL vs TCD (black), TCD vs UCD (blue), and UCD vs CTRL (red). C Singscores (y-axis) of an external validation cohort stratified by CeD condition (x-axis) for clusters 2 and 3 (left), cluster 2 (centre), and cluster 3 (right). Statistical tests as in panel A. D ROC curve and AUC for classifying external samples into CTRL or active CeD using cluster-specific singscores (red).

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