Fig. 2: Arg318 location in a DNMT3A 3D structural model and methylation profile for DNMT3A-mutated tumors.
From: Gain-of-function mutations in DNMT3A in patients with paraganglioma
(a) PyMOL representation of the interactions between the PWWP domain of DNMT3B and trimethlyated K36 in histone H3 (similar to the one depicted in Fig. 2a). The histone peptide is shown in yellow and the aromatic cage residues in blue. The tryptophan that substitutes the arginine 318 amino acid (equivalent to lysine 251 in DNMT3B) in the mutated Arg318Trp-DNMT3A sample is represented in dark red. (b) Hierarchical clustering using methylation data from the 3,092 probes significantly differentially methylated (FDR <0.05) between c.896A>T DNMT3A-mutated and nonmutated tumors. T1–T3: c.896A>T DNMT3A-mutated PGLs. H&N head and neck, PGL paraganglioma, PCC pheochromocytoma, TAP thoracic, abdominal or pelvic
