Table 4 Patients meeting NF2 criteria after therapeutic radiotherapy aged <20 years

From: Identifying the deficiencies of current diagnostic criteria for neurofibromatosis 2 using databases of 2777 individuals with molecular testing

Patient ID

Age radiotherapy (in 5-year age group)

Indication

Sites

NF2 criteria

Delay to criteria being met in years

Tumor NF2 analysis

Lymphocyte NF2 analysis

9803462

15–19

VS

Brain

Bilateral VS

12

-

Nil found

937087

0–4

Neuroblastoma

Brain & spine

Unilateral VS + 2 spinal schwannoma

25

Nil found

Nil found

157731

15–19

Lymphoreticular malignancy

Brain & spine

Unilateral VS + 2 schwannoma

22

c.1574+1G>A + LOH

Nil found

9869906

5–9

Neurogenic tumor unrelated to NF2

Brain

Left VS, trigeminal schwannoma, C4 schwannoma

22

-

Nil found

9000765

0–4

Lymphoreticular malignancy

Brain & spine

Unilateral VS + 2 meningiomas C3/4 schwannoma

25

-

Nil found

9116

5–9

Meningioma

Brain

Bilateral VS

2

-

c.241-9A>G

  1. LOH loss of heterozygosity, NF2 neurofibromatosis type 2, VS vestibular schwannoma.