Table 1 NGS multigene cancer panel gene lists

From: Detection of structural variation using target captured next-generation sequencing data for genetic diagnostic testing

Cancer panel

# of genes

Gene list

Breast cancer

17

ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, MRE11A, MUTYH, NBN, NF1, PTEN, RAD50, RAD51C, RAD51D, TP53, PALB2

Colorectal cancer

17

APC, BMPR1A, CDH1, CHEK2, EPCAM, GREM1, MLH1, MSH2, MSH6, MUTYH, PMS2,a POLD1, POLE, PTEN, SMAD4, STK11, TP53

Paragangliomas/pheochromocytomas

12

FH, MAX, MEN1, NF1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, TMEM127, VHL

Renal cancer

19

MLH1, MSH2, MSH6, PMS2,a PTEN, TP53, VHL, EPCAM, FLCN, TSC2, TSC1, SDHB, MET, MITF, SDHC, SDHD, SDHA, FH, BAP1

Pancreatic cancer

13

APC, ATM, BRCA1, BRCA2, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PMS2,a STK11, TP53, PALB2

Ovarian cancer/uterine cancer

24

ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, EPCAM, MLH1, MRE11A, MSH2, MSH6, MUTYH, NBN, NF1, PMS2,a PTEN, RAD50, RAD51C, RAD51D, STK11, TP53, PALB2, SMARCA4

Melanoma

7

BAP1, BRCA2, CDK4, CDKN2A, MITF, PTEN, TP53

  1. aPMS2 is excluded from SV analysis due to pseudogene interference (see “Patient samples” in the “Materials and Methods”).
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