Fig. 3
Predicted Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) breast cancer risk for a female intermediate-risk rare pathogenic variant carrier, on the basis of the different predictors of risk (questionnaire-based risk factors [QRFs], mammographic density [MD], and polygenic risk scores [PRS]). (a, c) Lifetime risk (age 20 to 80 years) for a CHEK2 1100delC carrier with unknown family history; (b, d) lifetime risk for a CHEK2 1100delC carrier with her mother affected at age 50. (e, f) Risk for a PALB2 and an ATM rare pathogenic variant carrier respectively, both with unknown family history. The backgrounds of the graphs are shaded to indicate the familial breast cancer risk categories based on the National Institute for Health and Care Excellence (NICE) guidelines:3 (1) near-population risk shaded in pink (<17%), (2) moderate risk shaded in yellow (≥17% and <30%), and (3) high risk shaded in blue (≥30%). Predictions based on UK breast cancer incidence.
