Table 1 Predicted distributions of women in the population in different risk categories (based on NICE guidelines3)
Based on 10-year risk (between ages 40–50 years) | Based on lifetime risk (between ages 20–80 years) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Family history | QRF only | QRF and MD | PRS only | QRF, MD, and PRS | QRF only | QRF and MD | PRS only | QRF, MD, and PRS | |
Unknown family history: Fig. 1 | Average population risk (%) | 1.7 | 11.5 | ||||||
% Women at near-population risk | 98.2 | 90.7 | 90.0 | 86.4 | 97.0 | 90.5 | 89.2 | 84.2 | |
% Women at moderate risk | 1.8 | 9.2 | 10.0 | 13.0 | 3.0 | 9.5 | 10.6 | 14.7 | |
% Women at high risk | 0.0 | 0.0 | 0.0 | 0.6 | 0.0 | 0.0 | 0.2 | 1.1 | |
Breast cancer risk for women with a combination of risk factors equivalent to a RR=0.3, relative to the population risk (%) | 0.5 | 3.6 | |||||||
% of women with risk less than RR=0.3 (low risk) | 0.0 | 3.0 | 3.6 | 12.1 | 0.0 | 0.7 | 0.1 | 2.9 | |
Mother affected at age 50: Fig. 2 | % Women at near-population risk | 36.6 | 47.5 | 55.0 | 60.1 | 35.1 | 42.3 | 52.3 | 55.1 |
% Women at moderate risk | 63.4 | 50.5 | 44.4 | 36.2 | 64.4 | 53.6 | 45.6 | 38.0 | |
% Women at high risk | 0.1 | 2.0 | 0.6 | 3.7 | 0.5 | 4.1 | 2.1 | 6.8 | |
