Table 2 Summary of components of the BOADICEA breast cancer risk model
Risk factor group | Risk factor category | Comments |
|---|---|---|
Family history | Explicit family history of breast and other cancers (ovarian, prostate, male breast, pancreatic) | Considers families of arbitrary size or structure, including affected and unaffected relatives |
Sex | Sex of all family members | |
Age | Ages at cancer diagnosis or current ages/age at death of all family members | |
Genetic factors | ||
Rare truncating/pathogenic variants | BRCA1 | |
BRCA2 | ||
PALB2 | ||
CHEK2 | ||
ATM | ||
Common genetic variants | Polygenic risk score | 313-SNP polygenic risk score, explaining 20% of the polygenic variance |
Unobserved genetic effects | Residual polygenic component | Accounts for the residual familial aggregation of breast cancer |
Lifestyle/hormonal/reproductive | ||
Height | Measured in cm (5 categories) | |
Body mass index | Measured in kg/m2 (4 categories) | |
Parity | Number of live births (4 categories) | |
Age at first birth | Measured in years (4 categories) | |
Age at menarche | Measured in years (7 categories) | |
Age at menopause | Measured in years (5 categories) | |
Use of oral contraceptive | Never/former/current | |
Use of hormone replacement therapy | Never/former any type/current estrogen only type/current other type | |
Alcohol intake | Measured in grams per day (7 categories) | |
Mammographic density | Measured using the BI-RADS breast composition categories (4 categories) | |
Breast tumor pathology | Estrogen receptor status | |
Progesterone receptor status | ||
HER2 receptor status | ||
CK14 status | Basal subtype status | |
CK5/6 status | Basal subtype status | |
Demographic factors | ||
Country of origin | Country | Defines the underlying incidences used |
Birth cohort | Defined by the person’s year of birth | 8 calendar year–specific sets of incidences |
Family ethnicity | Ashkenazi Jewish origin | |
