Table 2 Sensitivity: projection length ($AU) and annual discount rates

From: Long-term economic impacts of exome sequencing for suspected monogenic disorders: diagnosis, management, and reproductive outcomes

5% Annual discount

ICER at 20 years

ICER at 30 years

ICER at 40 years

ICER at 50 years

ICER at 60 years

 Model 1: cohort

$31,144.35

$25,638.73

$23,291.17

$22,112.50

$21,477.44

 Model 2: cohort and first-degree relative cascade testing

$20,839.57

$15,681.53

$13,783.00

$12,895.54

$12,431.37

 Model 3: cohort, first-degree relative cascade testing, and parental reproductive outcomes

$14,235.28

$11,455.57

$10,377.60

$9866.80

$9615.91

3.5% Annual discount

ICER at 20 years

ICER at 30 years

ICER at 40 years

ICER at 50 years

ICER at 60 years

 Model 1: cohort

$27,933.72

$22,248.14

$19,689.89

$18,311.83

$17,503.08

 Model 2: cohort and first-degree relative cascade testing

$18,188.31

$13,162.53

$11,234.11

$10,274.10

$9729.03

 Model 3: cohort, first-degree relative cascade testing, and parental reproductive outcomes

$12,796.23

$9958.90

$8809.62

$8227.69

$7921.78

0% Annual discount

ICER at 20 years

ICER at 30 years

ICER at 40 years

ICER at 50 years

ICER at 60 years

 Model 1: cohort

$21,397.07

$15,679.05

$12,957.44

$11,377.03

$10,356.12

 Model 2: cohort and first-degree relative cascade testing

$13,077.13

$8641.12

$6877.60

$5940.66

$5353.31

 Model 3: cohort, first-degree relative cascade testing, and parental reproductive outcomes

$9847.65

$7069.60

$5914.35

$5290.70

$4962.49

  1. ICER incremental cost-effectiveness ratio, QALY quality adjusted life-year.