Table 3 Sensitivity: cost of ES ($AU)

From: Long-term economic impacts of exome sequencing for suspected monogenic disorders: diagnosis, management, and reproductive outcomes

Price of ES

Costs

QALYs

ICER

Model 1: cohort outcomes

  $3100 (Base model)

$230,429.34

7.43

$31,013.37

  $1500

$102,429.34

7.43

$13,785.91

  $2000

$142,429.34

7.43

$19,169.49

  $2570.84

$188,096.54

7.43

$25,315.82

Model 2: cohort and cascade testing of first-degree relatives

  $3100 (Base model)

$242,269.97

11.69

$20,724.55

  $1500

$114,269.97

11.69

$9775.02

  $2000

$154,269.97

11.69

$13,196.75

  $2570.84

$199,937.17

11.69

$17,103.27

Model 3: cohort, cascade, and parental reproductive outcomes

  $3100 (Base model)

$512,296.95

36.07

$14,202.85

  $1500

$384,296.95

36.07

$10,654.20

  $2000

$424,296.95

36.07

$11,763.15

  $2570.84

$469,964.15

36.07

$13,029.23

  1. ES exome sequencing, ICER incremental cost-effectiveness ratio, QALY quality adjusted life-year.
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