Fig. 2

Markov model of the natural history of a patient with a genetic diagnosis of dilated cardiomyopathy. The natural history of disease was simulated using a Markov model. Every year patients can remain in their current risk state, progress to mild dilated cardiomyopathy, dilated cardiomyopathy, or death. When patients are in the mild dilated cardiomyopathy or dilated cardiomyopathy health state they can progress to the implantable cardioverter defibrillator state or the death state (sudden cardiac death or other causes).