Fig. 1 | Genetics in Medicine

Fig. 1

From: Pathogenic variants in the DEAH-box RNA helicase DHX37 are a frequent cause of 46,XY gonadal dysgenesis and 46,XY testicular regression syndrome

Fig. 1

Histologic analysis of gonad samples from three affected children. (a) Right gonad of patient 12 with no evidence of testicular tissue and, at higher magnification in (b) epididymal-like structure. (c) Left “streak” gonad of homogeneous fibrous-like stromal tissue from the same child. (d–e) Histology from patient 10. No gonadal tissue was observed, however remnants of the ductus deferens were present on the sample from the right side (d, black arrows) and epididymal-like tissue was observed on the left side (e). (f) Epipidymal-like structures from patient 6. Size bars are indicated for each panel. Staining was performed with hematoxylin–eosin–saffron.

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