Table 1 Ischemic cardiovascular and bleeding event risk by CYP2C19 status and P2Y₁₂ inhibitor maintenance therapy in patients initiated on clopidogrel during the index PCI (n = 601)

Clinical outcome by	Event	Event rate	Log-rank P value^d	Log-rank P value^d	Adjusted HR	P value
CYP2C19 phenotype–selected P2Y₁₂ inhibitor	No. (%)^a	(Per 100 patient-years)^c	(Unadjusted)	(Adjusted)	(95% CI)	P value
MACCE or clinically significant bleeding events
Continue clopidogrel (IM/PM)	24 (27.6%)	51.8			2.89 (1.44–6.13)	0.003
Continue clopidogrel (UM/RM/NM)	74 (17.5%)	26.6			1.37 (0.76–2.70)	0.304
Escalation to prasugrel/ticagrelor (IM/PM)	12 (13.3%)	19.4	P = 0.007	P = 0.003	Reference
MACCE
Continue clopidogrel (IM/PM)^b	23 (26.4%)	49.5			5.72 (2.41–15.8)	<0.001
Continue clopidogrel (UM/RM/NM)	59 (13.9%)	20.9			2.27 (1.04–5.96)	0.038
Escalation to prasugrel/ticagrelor (IM/PM)	6 (6.7%)	9.5	P < 0.001	P < 0.001	Reference
Clinically significant bleeding events
Continue clopidogrel (IM/PM)^b	2 (2.3%)	4.3			0.46 (0.07–2.07)	0.329
Continue clopidogrel (UM/RM/NM)	20 (4.7%)	7.2			0.64 (0.26–1.81)	0.378
Escalation to prasugrel/ticagrelor (IM/PM)	6 (6.7%)	9.7	P = 0.587	P = 0.559	Reference

CI confidence interval, HR hazard ratio, IM intermediate metabolizer, MACCE major adverse cardiovascular or cerebrovascular event, NM normal metabolizer, PCI percutaneous coronary intervention, PM poor metabolizer, RM rapid metabolizer, UM ultrarapid metabolizer.
^aData are presented as the number (%) of patients in each group who experienced the event over 12 months of follow-up after the index PCI.
^bDue to the rare use of clopidogrel in CYP2C19 PMs, 22 of the 23 MACCE events and both bleeding events in this group occurred in IMs.
^cThe event rate was calculated as the number of events per 100 patient-years of follow-up.
^dUnadjusted and covariate-adjusted log-rank P values across the three CYP2C19 phenotype-antiplatelet strata. The small subset of 11 patients with an UM/RM/NM phenotype who were escalated to alternative (prasugrel or ticagrelor) therapy were not included in the analysis.

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