Fig. 2 | Genetics in Medicine

Fig. 2

From: The Genomics Research and Innovation Network: creating an interoperable, federated, genomics learning system

Fig. 2

The PIC-SURE application programming interface (API) is used to access genotype and phenotype data from databases at each site of care. Currently the databases are i2b2/TranSMART instances, but the API is agnostic. Authorized investigators from the three institutions can log in with their standard hospital credentials at the Genomics Research and Innovation Network (GRIN) Central Access Portal. Investigators can interrogate data all three hospitals using the discover portal, which returns aggregate counts by institution. With proper institutional review board (IRB) authorization, they can access line-level de-identified data for exploratory analyses using i2b2/TranSMART, or export line-level data to the analysis portal, an Amazon Web Services (AWS)–hosted environment shared across the three institutions.

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