Fig. 3: Forest plot for frequency of movement disorders.

Patients identified by newborn screening (NBS) show a significantly lower rate of movement disorders than patients identified by targeted metabolic studies (TMS). CI confidence interval, RE random effect. Test of moderators (coefficient[s] 2): QM(df = 1) = 41.50, p < 0.0001. I2 (residual heterogeneity/unaccounted variability): 71.93%. Funnel plot showed no remarkable publication bias. (for details see Fig. S3).