Fig. 5: Forest plot for effect of delayed emergency treatment (ET) on development of acute onset movement disorder (MD) in patients identified by newborn screening (NBS) including and excluding noninformative studies. | Genetics in Medicine

Fig. 5: Forest plot for effect of delayed emergency treatment (ET) on development of acute onset movement disorder (MD) in patients identified by newborn screening (NBS) including and excluding noninformative studies.

From: Impact of newborn screening and quality of therapy on the neurological outcome in glutaric aciduria type 1: a meta-analysis

Fig. 5

Patients with delayed ET show an increased relative risk (log risk ratio) for development of an acute onset MD compared with patients with adequate ET (p < 0.0001). The relative risk increases further if noninformative studies are excluded (p < 0.0001). CI confidence interval, RE random effect. Including noninformative studies: test of heterogeneity: QM(df = 9) = 6.26, p = 0.7132; model results: p < 0.0001. I2 (residual heterogeneity/unaccounted variability): 0%. Excluding noninformative studies: test of heterogeneity QM(df = 3) = 2.1756, p = 0.5368; model results: p < 0.0001. I2 (residual heterogeneity/unaccounted variability): 0%.

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