Fig. 2: Somatic variants in 11 tumors available from patients with a germline variant.
From: Prevalence of pathogenic germline variants in patients with metastatic renal cell carcinoma
For loss of heterozygosity (LOH) analysis (upper panel) tumors were sequenced with the hereditary cancer panel (n = 29 genes). Somatic variants in renal cell carcinoma (RCC) predisposition genes are shown in dark gray and variants in other cancer genes in light gray. For one tumor sample, these sequencing data were not available (in black). Somatic variants in genes commonly mutated in RCC tumors (n = 43 genes analyzed) are presented in the lower panel. High impact variants (loss of function) are shown in dark squares and those with moderate impact (missense and inframe indels) are shown in striped squares. The allele frequencies of the tumor variants are provided inside the squares.
