Table 1 Characteristics of RCC patients in the unselected metastatic (n = 294) and the clinical RCC hereditary features (n = 21) cohorts.
From: Prevalence of pathogenic germline variants in patients with metastatic renal cell carcinoma
Patients characteristics | Unselected metastatic RCC (n = 294) | Selected hereditary RCC features (n = 21) |
|---|---|---|
Age at diagnosis, years | ||
Median [IQR] | 60 [51–69] | 43 [39–56] |
(Min, max) | (20, 87) | (30, 65) |
Age 46 or younger | 33 (11%) | 14 (67%) |
Age 47 or older | 259 (88%) | 7 (33%) |
Not available | 2 (0.7%) | 0 |
Sex | ||
Female | 97 (33%) | 8 (38%) |
Male | 196 (67%) | 13 (62%) |
Not available | 1 (0.3%) | - |
Nephrectomy | ||
Yes | 239 (81%) | 21 (100%) |
No | 22 (8%) | 0 (0%) |
Not available | 33 (11%) | |
Tumor histologic subtype | ||
Clear cell | 226 (77%) | 14 (67%) |
Papillary | 25 (9%) | 5 (24%) |
Type 1 | 1 (0.3%) | 1 (5%) |
Type 2 | 7 (2%) | 2 (10%) |
Undefined if type 1 or 2 | 17 (6%) | 1 (5%) |
Type 1 and 2, bilateral | 0 (0%) | 1 (5%) |
Chromophobe | 15 (5%) | 1 (5%) |
Collecting tube | 2 (0.7%) | 0 (0%) |
Unclassified | 2 (0.7%) | 0 (0%) |
Others | 3 (1%) | 1 (5%) |
Not available | 21 (7%) | 0 (0%) |
Metastatic disease | ||
Yes | 294 (100%) | 15 (71%) |
No | 0 | 6 (29%) |
Metastasis at diagnosis | ||
Yes | 95 (32%) | 7 (33%) |
No | 161 (55%) | 14 (66%) |
Not available | 38 (13%) | 0 (0%) |
History of cancers | ||
Personal history in cancer/in RCC | 16 (10%)/4 (2%)a | 7 (33%)/6 (29%) |
Family history in cancer/in RCC | 27 (21%)/5 (4%)b | 7 (33%)/4 (19%) |
