Table 4 Odds of favorable prior authorization outcome when submitted with diagnostic codes.

From: Outcomes of prior authorization requests for genetic testing in outpatient pediatric genetics clinics

Test type, diagnostic category (ICD-10-CM)

ICD code present

ICD code absent

Odds of favorable outcome with diagnostic code present,a odds ratio (95% confidence interval)

p value

Exome sequencing

 Autism (F84.0)

80/114 (70.2%)

443/659 (67.2%)

1.15 (0.74–1.77)

0.534

 Developmental delay (F80.4, F82, F88, F80.9, R62.50)

189/290 (65.2%)

334/483 (69.2%)

0.83 (0.61–1.14)

0.252

 Intellectual disability (F79, F70–78, F81.9)

43/65 (66.2%)

480/708 (67.8%)

0.93 (0.54–1.59)

0.786

 Seizures and epilepsy (G40–40.919)

22/35 (62.9%)

501/738 (67.9%)

0.80 (0.40–1.62)

0.534

 Multiple congenital anomalies (Q89.7)

22/33 (66.7%)

501/740 (67.7%)

0.95 (0.46–2.00)

0.901

CMA

 Autism (F84.0)

241/260 (92.7%)

1,145/1,307 (87.6%)

1.79 (1.09–2.94)

0.019

 Developmental delay (F80.4, F82, F88, F80.9, R62.50)

489/548 (89.2%)

897/1,019 (88.0%)

1.13 (0.81–1.57)

0.476

 Intellectual disability (F79, F70–78, F81.9)

120/134 (89.6%)

1,266/1,433 (88.3%)

1.13 (0.64–2.01)

0.676

 Seizures and epilepsy (G40–40.919)

31/38 (81.6%)

1,355/1,529 (88.6%)

0.57 (0.25–1.31)

0.180

 Multiple congenital anomalies (Q89.7)

52/57 (91.2%)

1,334/1,510 (88.3%)

1.37 (0.54–3.48)

0.504

  1. Bold values indicate statistical significance p  < 0.05.
  2. CMA chromosomal microarray, ICD-10-CM International Classification of Diseases, Tenth Revision, Clinical Modification.
  3. aFavorable outcome includes both prior authorization approval and prior authorization not required.