Fig. 4: Case presentation of improved tumor-associated bone mineral density (BMD) following MEKi therapy. | Genetics in Medicine

Fig. 4: Case presentation of improved tumor-associated bone mineral density (BMD) following MEKi therapy.

From: A molecular basis for neurofibroma-associated skeletal manifestations in NF1

Fig. 4

(a) Difference in BMD between left and right legs is shown for 9 individuals without leg neurofibroma (NF) (gray circles) and one patient with a left-leg NF (blue diamond) at baseline (left) and following 1-year MEKi therapy (right). Magnetic resonance image (MRI) shows left-sided tumor involvement and volumetric reduction following therapy. (b, c) Height adjusted total hip (b) and femoral neck (c) Z-scores at baseline and following 1-year MEKi therapy.

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