Table 1 Clinical characteristics of congenital diaphragmatic hernia (CDH) patients.
All patients (n = 647) | Patients with genetic data (n = 462) | |||
|---|---|---|---|---|
Number | Percent/mean (SD) | Number | Percent/mean (SD) | |
Neonatal factors | ||||
Parental Hollingshead score (socioeconomic status) | 422 | 41.9 (12.9) | 352 | 42.7 (13.0) |
Father: college or greater | 511 | 35.6% | 406 | 39.2% |
Mother: college or greater | 524 | 42.8% | 409 | 47.4% |
Family annual income <$30,000 | 501 | 36.3% | 393 | 30.3% |
White and non-Hispanic race | 555 | 75.1% | 444 | 78.4% |
Female sex | 638 | 42.3% | 462 | 43.5% |
Inborn in enrolling clinical site | 608 | 58.6% | 449 | 61.2% |
Prenatal diagnosis | 621 | 74.5% | 457 | 75.5% |
Gestational age, weeks | 623 | 37.7 (2.0) | 460 | 37.7 (2.0) |
Birth weight, z-score | 605 | −0.32 (1.1) | 453 | −0.26 (1.1) |
Birth length, z-score | 567 | 0.30 (1.4) | 428 | 0.33 (1.4) |
Birth head circumference, z-score | 541 | 0.39 (1.4) | 405 | 0.45 (1.4) |
Apgar 1 minute | 604 | 4.93 (2.5) | 446 | 5.05 (2.5) |
Apgar 5 minute | 601 | 6.93 (2.1) | 443 | 7.07 (2.0) |
Diagnosis | ||||
Left lesion side | 629 | 82.3% | 462 | 82.9% |
Additional congenital anomalies (complex CDH) | 623 | 36.8% | 461 | 36.9% |
Pulmonary hypertension (PH) at 1 month | 399 | 55.6% | 335 | 53.1% |
PH at 3 months | 306 | 19.6% | 268 | 19.0% |
Treatment | ||||
Diaphragm repaired with patch | 566 | 53.7% | 432 | 61.3% |
Extracorporeal membrane oxygenation (ECMO) | 618 | 31.5% | 455 | 30.1% |
Inhaled nitric oxide | 599 | 52.2% | 450 | 53.1% |
Tracheostomy | 587 | 4.4% | 443 | 3.8% |
Oxygen required at 28 days | 481 | 68.8% | 279 | 63.4% |
Oxygen required at discharge | 77 | 16.1% | 369 | 16.3% |
Tube feeding at discharge | 474 | 49.2% | 367 | 49.6% |
