Table 2 Patient demographics, measures of complexity, and phenotypic groupings.

From: A cost-effectiveness analysis of genomic sequencing in a prospective versus historical cohort of complex pediatric patients

Characteristic

Historical cohort N = 91

Prospective cohort N = 92

P value

Female (%)

48 (52)

43 (47)

0.5

Male (%)

43 (47)

49 (53)

0.5

Mean age at presentation for tertiary investigation in months (range)

13 (0–187)

19.8 (0–210)

0.16

Mean interval to genetics assessment in days (range)

106 (0–902)

133 (0–825)

0.34

Median number of specialists involved (range)

5 (2–8)

5 (2–9)

0.7

Median number of organs involved (range)

3 (1–7)

3 (1–9)

0.2

Median number of hospital admissions for investigation per child (range)

2 (0–11)

2 (0–8)

0.2

Phenotypic group: multiple congenital malformation

16

32

0.005

Phenotypic group: neurodevelopmental

63

49

0.001

Phenotypic group: multisystem disorder

6

8

0.55

Phenotypic group: high acuity, single system

6

3

0.19

  1. p values in bold are statistically significant (<0.05).