Table 1 Performance of noninvasive prenatal screening (NIPS) as a first-tier screening test.
From: Outcome of publicly funded nationwide first-tier noninvasive prenatal screening
Incidence | Sensitivity | Specificity | PPV | NPV | |||||
|---|---|---|---|---|---|---|---|---|---|
% | % | 95% CI | % | 95% CI | % | 95% CI | % | 95% CI | |
Trisomy 21 | 0.32 | 98.91 | 97.24–99.58 | 99.98 | 99.97–99.99 | 92.39 | 89.34–94.61 | 100.00 | 99.99–100.00 |
Trisomy 18 | 0.07 | 97.47 | 91.23–99.30 | 99.99 | 99.98–99.99 | 84.62 | 75.82–90.61 | 100.00 | 100.00–100.00 |
Trisomy 13 | 0.06 | 100.00 | 90.36–100.00 | 99.97 | 99.96–99.98 | 43.90 | 33.67–54.68 | 100.00 | 100.00–100.00 |
