Fig. 3: Kaplan–Meier estimated probabilities of a male (blue) vs. female (red) sex effect as a function of age in the different subgroups of pathogenic variants in the FBN1 gene. | Genetics in Medicine

Fig. 3: Kaplan–Meier estimated probabilities of a male (blue) vs. female (red) sex effect as a function of age in the different subgroups of pathogenic variants in the FBN1 gene.

From: Clinical relevance of genotype–phenotype correlations beyond vascular events in a cohort study of 1500 Marfan syndrome patients with FBN1 pathogenic variants

Fig. 3

Left panel: premature termination codon (PTC) (top), in-frame variants (bottom). Right panel: (top) patients with in-frame pathogenic variants associated with cysteine loss (-Cys), (middle) addition (+Cys), (bottom) no change in the cysteine content change (noCys).

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