Table 3 Predicted gene expression in lung–COVID-19 associations for the putative causal genes based on the COVID-19 Host Genetics Initiative data.

From: An integrative multiomics analysis identifies putative causal genes for COVID-19 severity

Chr

Gene

R2a

Number of predicting snps

Hospitalized patients versus population controls

Very severe respiratory confirmed COVID versus controls

OR (95% CI)b

P valuec

OR (95% CI)b

P valued

3

CCR2

0.01

4

2.81 (1.37–5.76)

4.71 × 10−3

5.50 (1.75–17.25)

3.49 × 10−3

17

WNT3

0.16

19

0.79 (0.70–0.90)

4.85 × 10−4

0.81 (0.66–0.98)

0.03

21

IFNAR2

0.10

127

0.74 (0.65–0.84)

3.01 × 10−6

0.84 (0.70–1.00)

0.05

  1. aR2: model prediction performance (R2).
  2. bOdds ratio (OR) and confidence interval (CI) per one standard deviation increase in genetically predicted gene expression.
  3. cP value derived from association analyses of 9,986 hospitalized patients and 1,877,672 population controls (two-sided).
  4. dP value derived from association analyses of 5,101 very severe respiratory confirmed COVID patients and 1,383,241 population controls (two-sided).
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