Fig. 1: CONSORT flowchart of TOTEM study. | Genetics in Medicine

Fig. 1: CONSORT flowchart of TOTEM study.

From: Safety and efficacy of low-dose PI3K inhibitor taselisib in adult patients with CLOVES and Klippel–Trenaunay syndrome (KTS): the TOTEM trial, a phase 1/2 multicenter, open-label, single-arm study

Fig. 1

On the 19 subjects enrolled, 10 completed 26 weeks of taselisib therapy. All treated patients were analyzed for the primary outcome measure (safety), and 13/19 had anatomy that permitted analysis of the efficacy measure with DXA. DXA dual energy X-ray absorptiometry, MRI magnetic resonance imaging, QoL quality of life.

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