Fig. 6
Working domains of prediction methods corresponding to genetic architecture. Genetic architecture is defined by two dimensions. One dimension is complexity, defined by the number of genes that control a trait. The simplest traits are Mendelian traits, which are controlled by only a few genes. The complex traits are controlled by many genes. The other dimension is heritability. Each prediction method has its own dominant domain of genetic architecture defined by different levels of the two dimensions. These domains are conceptually illustrated by the areas colored with different shades of blue. For example, for a trait controlled by a small number of genes with high heritability, sBLUP is superior to others; whereas, for a trait with low heritability, cBLUP is much better than the other methods
