Fig. 1: Determination of the chromosomal breakpoint in the patient with schizophrenia.
From: LDB2 locus disruption on 4p16.1 as a risk factor for schizophrenia and bipolar disorder
a Idiogram of the translocation karyotype. b FISH analysis, using the lymphoblastoid cell lines (LCL) from the proband. Metaphase spread of LCLs showing BAC (RP11-141E13) hybridization signal to chromosome 4, derivative 4, and derivative 13. Loss of green signal (a white arrow) indicated deletion of this region. c, d Determination of breakpoint sequences of der (4) and der (13).
