Fig. 1: Results of this study.

A A portrait of the reported patient taken at 1 year of age and provided by her parents with written informed consent. The portrait shows the patient’s arched eyebrows, left internal strabismus, flat nasal bridge, anteverted nares, long philtrum, and small and tented mouth. B Sanger sequencing shows a heterozygous variant, c.1516C>T [p.Arg506*], only in the patient and not in her parents, indicating de novo occurrence.