Table 4 Diversity of different haplotypes at six HLA class I and class II loci.

From: Human leukocyte antigen super-locus: nexus of genomic supergenes, SNPs, indels, transcripts, and haplotypes

HLA-A

HLA-C

HLA-B

HLA-DRB1

HLA-DQA1

HLA-DQB1

No. cells

AH

(A) MHC Haplotype Project (Horton et al.35)

 A*01:01:01

C*06:02:01

B*40:01:01

DRB1*13:01:01

DQA1*01:03:01

DQB1*06:03:01

APD

60.x

 A*01:01:01

C*07:01:01

B*08:01:01

DRB1*03:01:01

DQA1*05:01:01

DQB1*02:01:01

COX

8.1

 A*02:01:01

C*03:04:01

B*15:01:01

DRB1*04:01:01

DQA1*03:03:01

DQB1*03:01:01

MCF

62.2

 A*02:01:01

C*06:02:01

B*57:01:01

DRB1*07:01:01

DQA1*02:01:01

DQB1*03:03:02

DBB

57.1

 A*03:01:01

C*07:02:01

B*07:02:01

DRB1*15:01:01

DQA1*01:02:01

DQB1*06:02:01

PGF

7.1

 A*26:01:01

C*05:01:01

B*18:01:01

DRB1*03:01:01

DQA1*05:01:01

DQB1*02:01:01

QBL

18.2

 A*29:02:01

C*16:01:01

B*44:03:01

DRB1*07:01:01

DQA1*02:01:01

DQB1*02:02:01

MANN

44.2/44.3

 A*32:01:01

C*05:01:01

B*44:02:01

DRB1*04:03:01

DQA1*03:01:01

DQB1*03:05:01

SSTO

44.x

(B) Norman et al. (2017) Haplotype Project11

 A*01:01:01

C*01:21

B*52:01:01

DRB1*15:02:01

DQA1*01:03:01

DQB1*06:01:01

1

52.x

 A*01:01:01

C*03:03:01

B*15:01:01

DRB1*13:01:01

DQA1*01:03:01

DQB1*06:03:01

1

62

 A*01:01:01

C*04:01:01

B*35:02:01

DRB1*11:02:01

DQA1*05:05:01

DQB1*03:01:01

1

35.5

 A*01:01:01

C*04:01:01

B*35:02:01

DRB1*11:04:01

DQA1*01:03:01

DQB1*06:03:01

1

35.x

 A*01:01:01

C*06:02:01

B*37:01:01

DRB1*16:01:01

DQA1*01:02:02

DQB1*05:02:01

1

–

 A*01:01:01

C*06:02:01

B*40:01:02

DRB1*13:01:01

DQA1*01:03:01

DQB1*06:03:01

1

60.x

 A*01:01:01

C*06:02:01

B*57:01:01

het

het

het

1

–

 A*01:01:01

C*07:01:01

B*08:01:01

DRB1*03:01:01

DQA1*05:01:01

DQB1*02:01:01

5

8.1

 A*01:01:01

C*07:01:01

B*49:01:01

DRB1*11:02:01

DQA1*05:05:01

DQB1*03:19

1

–

 A*01:01:01

C*17:01:01

B*41:01:01

DRB1*11:01:01

DQA1*05:05:01

DQB1*03:01:01

1

–

 A*02:01:01

C*01:02:01

B*27:05

DRB1*01:01:01

DQA1*01:01:01

DQB1*05:01:01

1

–

 A*02:01:01

C*02:02:02

B*27:05:02

DRB1*16:01:01

DQA1*01:02:02

DQB1*05:02:01

1

–

 A*02:01:01

C*02:02:02

B*40:02:01

DRB1*16:01:01

DQA1*01:02:02

DQB1*05:02:01

1

60.x

 A*02:01:01

C*03:04:01

B*15:01:01

DRB1*04:01:01

DQA1*03:01:01

DQB1*03:02:01

1

62.1

 A*02:01:01

C*04:01:01

B*35:01:01

DRB1*08:01:01

DQA1*04:01:01

DQB1*04:01:01

1

35.x

 A*02:01:01

C*05:01:01

B*44:02:01

DRB1*11:01:01

DQA1*01:02:02

DQB1*05:02:01

1

44.x

 A*02:01:01

C*05:01:01

B*44:02:01

DRB1*04:01:01

DQA1*03:03:01

DQB1*03:01:01

1

44.1

 A*02:01:01

C*05:01:01

B*44:02:01

DRB1*14:54:01

DQA1*01:04:01

DQB1*05:03:01

1

44.x

 A*02:01:01

C*06:02:01

B*57:01:01

DRB1*07:01:01

DQA1*02:01

DQB1*03:03:02

2

57.1

 A*02:01:01

C*07:01:01

B*57:01:01

DRB1*16:02:01

DQA1*01:02:02

DQB1*05:02:01

1

57.x

 A*02:01:01

C*12:03:01

B*35:03:01

het

het

het

1

–

 A*02:01:01

C*01:02:01

B*27:05:02

DRB1*08:01:01

DQA1*04:01:01

DQB1*04:01:01

1

–

 A*02:01:01

C*03:04:01

B*15:01:01

DRB1*04:01:01

DQA1*03:03:01

DQB1*03:01:01

2

62.x

 A*02:01:01

C*03:04:01

B*40:01:02

DRB1*08:01:01

DQA1*04:01:01

DQB1*04:02:01

1

60.2

 A*02:01:01

C*03:04:01

B*40:01:02

DRB1*13:02:01

DQA1*01:02:01

DQB1*06:04:01

1

60.3

 A*02:01:01

C*05:01:01

B*18:01:01

DRB1*11:02:01

DQA1*05:05:01

DQB1*03:01:01

1

18.x

 A*02:01:01

C*07:01:01

B*18:01:01

DRB1*12:01:01

DQA1*05:05:01

DQB1*03:01:01

1

18.x

 A*02:01:01

C*07:01:01

B*18:01:01

DRB1*14:54:01

DQA1*01:04:01

DQB1*05:03:01

1

18.x

 A*02:01:01

C*12:03:01

B*38:01:01

DRB1*13:01:01

DQA1*01:03:01

DQB1*06:03:01

1

38.x

 A*02:01:01

C*16:01:01

B*45:01:01

DRB1*13:01:01

DQA1*01:03:01

DQB1*06:03:01

1

–

 A*02:01:01

C*06:02:01

B*13:02:01

DRB1*07:01:01

DQA1*02:01

DQB1*02:02:01

1

13.1

 A*02:04

C*15:02:01

B*51:01:01

DRB1*16:02:01

DQA1*05:05:01

DQB1*03:01:01

2

51.x

 A*02:05:01

C*07:18:01

B*58:01:01

DRB1*03:01:01

DQA1*05:01:01

DQB1*02:01:01

1

58.x

 A*02:12

C*01:02:01

B*51:01:01

DRB1*08:01:01

DQA1*04:01:01

DQB1*04:02:01

1

51.x

 A*02:17:02

C*03:03:01

B*15:01:01

DRB1*03:02:01

DQA1*05:03

DQB1*03:01:01

2

62.x

 A*03:01:01

C*06:02:01

B*50:01:01

DRB1*07:01:01

DQA1*02:01

het

1

50.x

 A*03:01:01

C*07:02:01

B*07:02:01

DRB1*04:01:01

DQA1*03:01:01

DQB1*03:02:01

1

7.3

 A*03:01:01

C*07:02:01

B*07:02:01

DRB1*15:01:01

DQA1*01:02:01

DQB1*06:02:01

4

7.1

 A*11:01:01

C*04:01:01

B*35:01:01

DRB1*01:01:01

DQA1*01:01:01

DQB1*05:01:01

1

35.2

 A*11:01:01

C*04:01:01

B*35:03:01

DRB1*14:04

DQA1*01:04:02

DQB1*06:01:01

1

35.x

 A*23:01:01

C*05:01:01

B*14:01:01

DRB1*04:01:01

DQA1*03:01:01

DQB1*03:02:01

1

–

 A*24:02:01

C*01:02:01

B*54:01:01

DRB1*04:01:01

DQA1*03:03:01

DQB1*04:01:01

1

54.1

 A*24:02:01

C*03:04:01

B*40:01:02

DRB1*09:01:02

DQA1*03:02

DQB1*04:01:01

1

60.x

 A*24:02:01

C*04:01:01

B*15:01:01

DRB1*04:06:01

DQA1*03:01:01

DQB1*04:01:01

1

62.x

 A*24:02:01

C*04:01:01

B*35:08:01

DRB1*11:03

DQA1*05:05:01

DQB1*03:01:01

1

35.4

 A*24:02:01

C*01:02:01

B*56:01

DRB1*16:01:01

DQA1*01:02:02

DQB1*05:02:01

1

–

 A*24:02:01

C*12:02:02

B*52:01:01

DRB1*15:02:01

DQA1*01:03:01

DQB1*06:01:01

2

52.1

 A*24:02:01

C*12:03:01

B*51:01:01

DRB1*01:01:01

DQA1*01:01:01

DQB1*05:01:01

1

51.x

 A*24:02:01

C*07:02:01

B*07:02:01

DRB1*01:01:01

DQA1*01:01:01

DQB1*05:01:01

1

7.2

 A*26:01:01

C*05:01:01

B*18:01:01

DRB1*03:01:01

DQA1*05:01:01

DQB1*02:01:01

1

18.2

 A*26:01:01

C*12:03:01

B*38:01:01

DRB1*04:02:01

DQA1*03:01:01

DQB1*03:02:01

1

38.1

 A*26:01:01

C*07:01:01

B*08:01:01

DRB1*15:01:01

DQA1*01:02:01

DQB1*06:02:01

1

8.x

 A*29:02:01

C*16:01:01

B*44:03:01

DRB1*04:01:01

DQA1*03:03:01

DQB1*03:01:01

1

44.x

 A*29:02:01

C*16:01:01

B*44:03:01

DRB1*07:01:01

DQA1*02:01

DQB1*02:02:01

2

44.2

 A*30:01:01

C*06:02:01

B*13:02:01

DRB1*07:01:01

DQA1*02:01

DQB1*02:02:01

1

13.x

 A*30:02:01

C*05:01:01

B*18:01:01

DRB1*03:01:01

DQA1*05:01:01

DQB1*02:01:01

2

18.x

 A*31:01:02

C*01:02:30

B*15:01:01

DRB1*08:02:01

DQA1*04:01:01

DQB1*04:02:01

1

62.x

 A*31:01:02

C*15:02:01

B*51:01:01

DRB1*04:07:01

DQA1*03:03:01

DQB1*03:01:01

1

51.x

 A*31:01:02

C*03:04:01

B*40:01:02

DRB1*04:04:01

DQA1*03:01:01

DQB1*03:02:01

1

60.1

 A*31:01:02

C*04:01:01

B*35:01:01

DRB1*04:01:01

DQA1*03:03:01

DQB1*03:01:01

1

35.x

 A*32:01:01

C*05:01:01

B*44:02:01

DRB1*13:02:01

DQA1*01:02:01

DQB1*06:04:01

1

44.x

 A*32:01:01

C*05:01:01

B*44:02:01

DRB1*04:03:01

DQA1*03:01:01

DQB1*03:05:01

1

44.x

 A*32:01:01

C*12:03:01

B*38:01:01

DRB1*11:01:01

DQA1*05:05:01

DQB1*03:01:01

1

38.x

 A*33:01:01

C*08:02:01

B*14:01:01

DRB1*01:02:01

DQA1*01:01:02

DQB1*05:01:01

1

65.1

 A*33:01:01

C*08:02:01

B*14:01:01

DRB1*07:01:01

DQA1*02:01

DQB1*02:02:01

1

64.x

 A*33:03:01

C*14:03

B*44:03:01

DRB1*13:02:01

DQA1*01:02:01

DQB1*06:04:01

1

44.4

 A*66:01:01

C*12:03:01

B*38:01:01

DRB1*14:01:01

DQA1*01:04:01

DQB1*05:03:01

1

38.x

 A*68:02:01

C*04:01:01

B*53:01:01

DRB1*15:03:01

DQA1*01:02:01

DQB1*06:02:01

1

–

     

Total

82

–

  1. The haplotypes in (A) and (B) were sorted according to the HLA-A allele in descending order. The AH nomenclature is taken from Dorak et al.47, which is based on the initial definitions by Dawkins et al.10 and Alper et al.9,18, whereby the AHs are also called CEHs. The AHs are named using the B allele, and if two or more AHs carry the same B allele then sequential numbers are added to indicate their order of discovery, such as AH7.1 and AH7.2. The ‘x’ after the B allele implies that the sequential number is not known, and therefore needs to be updated. A blank space in the AH column indicates that the AH designation is not known or updated in the literature. Norman et al.11 have provided the names of the cell-lines for each of the haplotypes sequenced, but we have not added them to this table for brevity, and prefer to indicate the number of different cell-lines that were sequenced with the same HLA class I and class II alleles.
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