Fig. 1 | Hypertension Research

Fig. 1

From: Co-treatment with clonidine and a GRK2 inhibitor prevented rebound hypertension and endothelial dysfunction after withdrawal in diabetes

Fig. 1

Effects of drug withdrawal on blood pressure and heart rate in DM mice. a Systolic blood pressure (SBP), b mean blood pressure (MBP), c diastolic blood pressure (DBP), and d heart rate. SBP, MBP, DBP, and heart rate before, during, and after systemic infusion of clonidine and/or the GRK2 inhibitor in control or DM mice were determined every 2 or 3 days. Control, control mice that were sham-operated; DM, DM mice that were sham-operated; DM-clo, DM mice that received clonidine infusions (125 µg kg−1 day−1) via an osmotic pump for 2 weeks and were then left to rest; DM-GRK2inh, DM mice that received GRK2-inhibitor infusions (5.64 ng kg−1 day−1) via an osmotic pump for 2 weeks and were then left to rest; DM-clo/GRK2inh, DM mice that received infusions of clonidine and the GRK2 inhibitor via an osmotic pump for 2 weeks and were then left to rest. Values represent the mean ± SE; n = 5

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