Fig. 3 | Hypertension Research

Fig. 3

From: Co-treatment with clonidine and a GRK2 inhibitor prevented rebound hypertension and endothelial dysfunction after withdrawal in diabetes

Fig. 3

Effects of drug withdrawal on GRK2 expression and activity 21 days after implantation of an osmotic pump in DM mice. a The expression levels of GRK2 were analyzed by western blotting in aortas from control, DM, clonidine-treated DM, GRK2-inhibitor-treated DM or clonidine/GRK2-inhibitor-cotreated DM mice and quantified by densitometric analysis. Data were normalized by β-actin protein levels. b Levels of GRK2 activity in aortas from control, DM, clonidine-treated DM, GRK2-inhibitor-treated DM, or clonidine/GRK2-inhibitor-cotreated DM mice. Values represent the mean ± SE; n = 5. *P < 0.05, ***P < 0.001 vs. Control. #P < 0.05 vs. DM mice

Back to article page