Table 1 Effects of drug withdrawal on blood pressure and heart rate 21 days after implantation of an osmotic pump in DM mice

From: Co-treatment with clonidine and a GRK2 inhibitor prevented rebound hypertension and endothelial dysfunction after withdrawal in diabetes

Parameters

Control

DM

DM-clo

DM-GRK2inh

DM-clo/GRK2inh

SBP (mmHg)

108 ± 4

131 ± 4***

125 ± 1**

126 ± 2**

110 ± 4###$

MBP (mmHg)

85 ± 3

106 ± 2***

100 ± 2*

106 ± 2***

88 ± 4##$

DBP (mmHg)

73 ± 2

93 ± 3***

84 ± 3

99 ± 2***

78 ± 4##

Heart rate (beats per min)

595 ± 13

621 ± 12

665 ± 10

623 ± 25

635 ± 16

  1. Values are means ± SE (n = 5)
  2. SBP systolic blood pressure, MBP mean blood pressure, DBP diastolic blood pressure
  3. *P < 0.05, **P < 0.01, ***P < 0.001 vs. Control, ##P < 0.01, ###P < 0.001 vs. DM, $P < 0.05 vs. DM-clo.
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