Table 3 Factors associated with the effectiveness of amlodipine and cilnidipine on BP variability

From: Comparison between L-type and N/L-type calcium channel blockers in the regulation of home blood-pressure variability in elderly hypertensive patients

Variables

Smaller CV with amlodipine group

Smaller CV with cilnidipine group

P

(a) BP variability in morning SBP

Log A/C CV

−0.17 ± 0.17

0.16 ± 0.10

 

Men/women

8/5

6/7

0.70

Age (years)

69.9 ± 5.5

71.9 ± 6.4

0.71

Body mass index (kg/m2)

23.8 ± 4.7

23.5 ± 2.5

0.82

eGFR (ml/min/1.73 m2)

62.2 ± 15.0

64.5 ± 11.1

0.66

HbA1c (%)

6.1 ± 0.5

5.9 ± 0.62

0.40

baPWV (cm/s)

1645.5 ± 397.9

1815.7 ± 390.9

0.32

Amlodipine

 Urinary total catecholamine (μg/gCr)

0.68 ± 0.33

1.40 ± 1.14

0.04

  Urinary adrenaline (μg/gCr)

0.0097 ± 0.27

0.017 ± 1.12

0.01

  Urinary noradrenaline (μg/gCr)

0.162 ± 0.07

0.19 ± 0.05

0.19

  Urinary dopamine (μg/gCr)

0.51 ± 0.01

1.19 ± 0.01

0.04

Cilnidipine

 Urinary total catecholamine (μg/gCr)

0.98 ± 0.91

1.11 ± 0.93

0.28

  Urinary adrenaline (μg/gCr)

0.013 ± 0.01

0.014 ± 0.01

0.74

  Urinary noradrenaline (μg/gCr)

0.17 ± 0.04

0.19 ± 0.08

0.81

  Urinary dopamine (μg/gCr)

0.80 ± 0.89

0.91 ± 0.88

0.85

(b) BP variability in evening SBP

Log A/C CV

−0.18 ± 0.14

0.14 ± 0.20

 

Men/women

10/ 5

4/ 7

0.23

Age (years)

69.7 ± 4.4

72.5 ± 7.6

0.24

Body mass index (kg/m2)

24.3 ± 3.2

22.9 ± 4.2

0.26

eGFR (ml/min/1.73 m2)

65.3 ± 13.8

60.6 ± 11.9

0.37

HbA1c (%)

6.1 ± 0.6

5.8 ± 0.5

0.23

baPWV (cm/s)

1555.6 ± 177.2

1974.5 ± 520.0

0.01

Amlodipine

  Urinary total catecholamine (μg/gCr)

0.98 ± 0.91

1.11 ± 0.93

0.73

    Urinary adrenaline (μg/gCr)

0.013 ± 0.007

0.014 ± 0.008

0.71

    Urinary noradrenaline (μg/gCr)

0.17 ± 0.04

0.19 ± 0.08

0.51

    Urinary dopamine (μg/gCr)

0.80 ± 0.89

0.91 ± 0.88

0.76

Cilnidipine

   

  Urinary total catecholamine (μg/gCr)

0.96 ± 0.54

1.40 ± 0.71

0.10

    Urinary adrenaline (μg/gCr)

0.012 ± 0.006

0.016 ± 0.007

0.15

    Urinary noradrenaline (μg/gCr)

0.14 ± 0.04

0.18 ± 0.06

0.08

    Urinary dopamine (μg/gCr)

0.81 ± 0.54

1.20 ± 0.68

0.12

  1. Values represent the mean ± standard deviation. Significance was determined using unpaired Student’s t-test or Fisher's exact test
  2. CV coefficient of variation, eGFR estimated glomerular filtration rate, HbA1c haemoglobin A1c, baPWV brachial-ankle pulse wave velocity
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