Table 1 Major prospective cohort studies evaluating the association of arterial stiffness with clinical outcomes and mortality in ESRD
Author | Year | n | Patient characteristics | Follow-up | Predictor | Outcome | Prognostic significance |
|---|---|---|---|---|---|---|---|
Blacher et al. [62] | 1999 | 241 | HD patients | 72 mo | Aortic PWV | ACM CVM | Aortic PWV > 12 m/s vs aortic PWV < 9.4 m/s was an independent predictor of ACM and CVM (OR: 5.4; 95% CI: 2.4–11.9 for ACM and OR: 5.9; 95% CI: 2.3–15.5 for CVM) |
Shoji et al. [51] | 2001 | 265 | HD patients | 63 mo | Aortic PWV | ACM | Each 1 m/s increase in aortic PWV was associated with 18% elevated risk of ACM (HR: 1.18; 95% CI: 1.01–1.39) |
Verbeke et al. [95] | 2011 | 1,084 | HD patients | 24 mo | Aortic PWV | CVM | Each 1 m/s increase in aortic PWV was associated with 15% elevated risk of CVM |
Verbeke et al. [65] | 2011 | 512 | Renal transplant recipients | 60 mo | Aortic PWV | CVM | Aortic PWV was independent predictor of future fatal and non-fatal CV events (HR: 1.35 per 1 SD increase; 95% CI: 1.10–1.65) |
Szeto et al. [64] | 2012 | 155 | PD patients | 24 mo | Aortic PWV | ACM | Aortic PWV > 10 m/s was associated with higher ACM rates as compared with aortic PWV < 10 m/s |
Fortier et al. [66] | 2015 | 310 | HD patients | 29 mo | Aortic-to-Brachial PWV ratio | ACM | Each 1-SD increase in the PWV ratio was associated with 43% higher risk of ACM (HR: 1.43; 95% CI: 1.24–1.64) |
London et al. [96] | 2016 | 156 | HD patients | 60 mo | Aortic PWV | ACM CVM | Aortic PWV was independent predictor of ACM (RR: 1.20; 95% CI: 1.06–1.36 for 1 m/s increase in PWV) and CVM (RR: 1.21; 95% CI: 1.03-1.41 for 1-m/s increase in PWV) |
Sarafidis et al. [63] | 2017 | 170 | HD patients | 28 mo | 48-h ambulatory PWV | ACM CVM | Ambulatory PWV was predictor of ACM and CVM independently from 48-hour brachial and central aortic ambulatory SBP (HR: 1.579; 95% CI, 1.187–2.102 for 1 m/s increase in PWV) |
