Table 5 Gene-based associations of Kir genes with blood pressure responses in the GenSalt study (TPM)

From: Association of Kir genes with blood pressure responses to dietary sodium intervention: the GenSalt study

 

Low-sodium intervention

High-sodium intervention

 

SBP

DBP

MAP

SBP

DBP

MAP

KCNJ10

0.18

0.17

0.19

0.13

0.14

0.11

KCNJ9

0.38

0.18

0.18

0.19

0.08

0.06

KCNJ3

0.62

0.46

0.67

0.17

0.35

0.24

KCNJ13

0.08

0.16

0.16

0.09

0.20

0.18

KCNJ11

0.11

0.22

0.20

0.14

0.19

0.15

KCNJ1

0.46

0.64

0.32

0.19

0.47

0.36

KCNJ5

0.63

0.47

0.52

0.57

0.57

0.65

KCNJ12

0.21

0.24

0.20

0.18

8.10 × 10−3

0.01

KCNJ16

0.36

0.23

0.45

0.41

0.12

0.05

KCNJ2

0.30

0.13

0.14

0.13

0.46

0.34

KCNJ14

0.04

0.05

0.03

0.12

0.02

0.03

KCNJ6

< 1.00 × 10−6 a

< 1.00 × 10−6 a

< 1.00 × 10−6 a

< 1.00 × 10−6 a

0.35

0.11

KCNJ15

0.40

0.41

0.46

0.61

0.71

0.35

KCNJ4

2.40 × 10-5 a

0.68

0.54

3.00 × 10−6 a

0.68

0.26

  1. DBP diastolic blood pressure, Kir inwardly rectifying potassium channel, MAP mean arterial pressure, SBP systolic blood pressure, SNP single-nucleotide polymorphism, TPM truncated product method
  2. aSignificant after adjustment for multiple testing using Bonferroni correction (α = 0.05/14 = 3.57 × 10−3)
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