Table 2 Change in renal variables at 52 weeks relative to baseline in the tertiles

From: Mineralocorticoid receptor blockade suppresses dietary salt-induced ACEI/ARB-resistant albuminuria in non-diabetic hypertension: a sub-analysis of evaluate study

 

Lowest tertile

Middle tertile

Highest tertile

 

Eplerenone

Placebo

p-valuea

Eplerenone

Placebo

p-valuea

Eplerenone

Placebo

p-valuea

Change in eGFR, ml/min/1.73 m2

−5.52 ± 5.35

0.46 ± 5.73

0.13

−3.75 ± 3.66

0.98 ± 3.52

0.06

−4.53 ± 3.78

−0.37 ± 3.86

0.10

Change in serum potassium, mEq/l

0.12 ± 0.14

−0.05 ± 0.15

0.05*

0.21 ± 0.13

0.05 ± 0.13

0.03**

0.19 ± 0.11

0.07 ± 0.11

0.06

Change in serum creatinine, μmol/l

0.046 ± 0.027

0.026 ± 0.030

0.31

0.043 ± 0.034

0.002 ± 0.032

0.50

0.034 ± 0.028

0.007 ± 0.030

0.60

  1. The data are presented as mean ± SD. eGFR estimated glomerular filtration rate
  2. aThe eplerenone and placebo groups in each tertile were compared by using t-test with Welch’s correlation
  3. *Significant p-value (p = 0.0498)
  4. **p < 0.05
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