Fig. 1 | Hypertension Research

Fig. 1

From: Sex difference in the mediation roles of an inflammatory factor (hsCRP) and adipokines on the relationship between adiposity and blood pressure

Fig. 1

Model of mediation analysis. X is the independent variable (PBF percentage of body fat), M is the potential mediator (hsCRP high sensitivity C-reactive protein, ADI adiponectin, or LEP leptin), and Y is the dependent variable (SBP systolic blood pressure, or DBP diastolic blood pressure). Association c: association between independent variable (X) and dependent variable (Y). Association a: association between X and potential mediation variable (M). Association b: association between M and Y after controlling for X. Association c′: association between X and Y after controlling for M. If a, b and c were all significant associations, the term of multiplying a and b (indirect association, a × b) was included as the mediation effect of M. The mediation ratio (% mediation) is the percentage mediation of the potential mediator (a × b/c)

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