Table 2 Association between inflammatory factor or adipokines, adiposity, and systolic blood pressure

From: Sex difference in the mediation roles of an inflammatory factor (hsCRP) and adipokines on the relationship between adiposity and blood pressure

Sex

Mediator

Independent variable

Dependent variable

Coefficienta

c path

a path

b path

Male

LN hsCRP (n = 454)

PBF

SBP

β (SE), P

0.246 (0.046), <0.001

0.454 (0.043), <0.001

0.072 (0.051), 0.155

 

LN ADI (n = 312)

PBF

SBP

β (SE), P

0.261 (0.057), <0.001

0.049 (0.058), 0.400

−0.133 (0.055), 0.016

 

LN leptin (n = 312)

PBF

SBP

β (SE), P

0.261 (0.057), <0.001

0.429 (0.053), <0.001

0.136 (0.061), 0.025

Female

LN hsCRP (n = 454)

PBF

SBP

β (SE), P

0.194 (0.034), <0.001

0.415 (0.033), <0.001

0.141 (0.037), <0.001

 

LN ADI (n = 312)

PBF

SBP

β (SE), P

0.167 (0.042), <0.001

0.032 (0.044), 0.470

0.017 (0.040), 0.662

 

LN leptin (n = 312)

PBF

SBP

β (SE), P

0.167 (0.042), <0.001

0.293 (0.042), <0.001

0.002 (0.041), 0.955

  1. SBP systolic blood pressure, PBF percentage of body fat, CRP C-reaction protein, ADI adiponectin, c total association between the independent variables (X = PBF) and the outcome variable (Y = SBP), a association between the independent variable (X = PBF) and the potential mediator (M = CRP/ADI/LEP), b association between M and Y(SBP) was examined, adjusted for the X.
  2. aAll the analyses were adjusted for age. Level of hsCRP, ADI and leptin were natural log transformed for mediation analysis
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