Table 3 Association between inflammatory factor or adipokines, adiposity, and diastolic blood pressure

From: Sex difference in the mediation roles of an inflammatory factor (hsCRP) and adipokines on the relationship between adiposity and blood pressure

Sex

Mediator

Independent variable

Dependent variable

Coefficienta

c path

a path

b path

Male

LN hsCRP (n = 454)

PBF

DBP

β (SE), P

0.229 (0.046), <0.001

0.454 (0.043), <0.001

0.042 (0.051), 0.155

 

LN ADI (n = 312)

PBF

DBP

β (SE), P

0.218 (0.057), <0.001

0.049 (0.058), 0.400

−0.076 (0.056), 0.016

 

LN leptin (n = 312)

PBF

DBP

β (SE), P

0.218 (0.057), <0.001

0.429 (0.053), <0.001

0.159 (0.061), 0.025

Female

LN hsCRP (n = 761)

PBF

DBP

β (SE), P

0.214 (0.035), <0.001

0.415 (0.033), <0.001

0.152 (0.038), <0.001

 

LN ADI (n = 584)

PBF

DBP

β (SE), P

0.207 (0.043), <0.001

0.032 (0.044), 0.470

0.003 (0.041), 0.662

 

LN leptin (n = 584)

PBF

DBP

β (SE), P

0.207 (0.043), <0.001

0.293 (0.042), <0.001

0.005 (0.042), 0.955

  1. DBP diastolic blood pressure, PBF percentage of body fat, CRP C-reaction protein, ADI adiponectin, c total association between the independent variables (X = PBF) and the outcome variable (Y = DBP), a association between the independent variable (X = PBF) and the potential mediator (M = CRP/ADI/LEP), b association between M and Y was examined, adjusted for the X
  2. aAll the analyses were adjusted for age. Mediator (M) = CRP/ADI/LEP for model 1/2/3. Level of hsCRP, ADI, and leptin were natural log transformed for mediation analysis
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