Table 1 Norepinephrine, creatinine and urea serum concentration of control, DOCA-salt–treated, DOCA-salt + MH-76–treated, DOCA-salt + MH-79–treated, and DOCA-salt + prazosin-treated rats at the end of the experimental period

From: Reversal of cardiac, vascular, and renal dysfunction by non-quinazoline α1-adrenolytics in DOCA-salt hypertensive rats: a comparison with prazosin, a quinazoline-based α1-adrenoceptor antagonist

Parameter

Control

DOCA-salt

DOCA-salt+MH-76

DOCA-salt+MH-79

DOCA-salt+prazosin

Biochemical parameters

  Norepinephrine (ng/ml)

10.3 ± 0.4

7.5 ± 0.7*

8.3 ± 0.6

8.9 ± 0.6

10.0 ± 0.6**

  Creatinine (nmol/ml)

104.1 ± 11.4

100.1 ± 10.4

104. ± 11.8

102.2 ± 6.4

86.1 ± 14.3

  Urea (ng/ml)

124.8 ± 6.0

134.5 ± 7.5

119.2 ± 7.7

128.0 ± 10.6

139.5 ± 7.4

  1. n = 7–8
  2. DOCA deoxycorticosterone acetate
  3. *P < 0.05 vs control, **P < 0.05 vs DOCA-salt
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