Table 1 Renal function after 7 days of 0.3 or 8% NaCl intake in sik1+/+ and sik1−/− mice

From: Acute salt loading induces sympathetic nervous system overdrive in mice lacking salt-inducible kinase 1 (SIK1)

 

0.3% NaCl diet

8% NaCl diet

 

sik1 +/+

sik1 −/−

sik1 +/+

sik1 −/−

Body weight (g)

25.7 ± 0.6

25.8 ± 1.1

29.2 ± 0.9#

28.2 ± 0.5

Kidney-to-body weight ratio (mg/g)

11.3 ± 0.2

13.0 ± 0.2*

12.6 ± 0.2#

13.9 ± 0.2*

Water intake (ml/24 h)

2.5 ± 0.2

3.3 ± 0.5

6.9 ± 0.6#

6.8 ± 0.7#

Urinary output (ml/24 h)

1.6 ± 0.2

1.0 ± 0.2

3.5 ± 0.7#

4.3 ± 0.6#

Urine creatinine (mg/24 h)

0.62 ± 0.03

0.48 ± 0.04

0.62 ± 0.04

0.57 ± 0.05

Urine sodium/creatinine ratio (µmol/mg)

119 ± 8

107 ± 11

2075 ± 450#

3041 ± 251* #

Urine potassium/creatinine ratio (µmol/mg)

220 ± 10

183 ± 13

251 ± 27

341 ± 15* #

Urine chloride/creatinine ratio (µmol/mg)

403 ± 36

405 ± 43

1719 ± 340#

2268 ± 157#

  1. Mean ± SEM, n = 5–6 per group. *P < 0.05 as compared with sik1+/+ mice; #P < 0.05 as compared with 0.3% NaCl feeding counterparts
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