Table 2 The significant m⁶A-SNPs for SBP in GWAS-2018

SNP rsID	Gene	CHR	Position^a	EA	EAF	GWAS							eQTL effect	Confidence level	m⁶A function^c
SNP rsID	Gene	CHR	Position^a	EA	EAF	β SBP	P SBP	β CAD	P CAD	β stroke	P stroke	Asian^b	eQTL effect	Confidence level	m⁶A function^c
rs56001051	C1orf167	1	11,838,841	G	0.10	−0.0378	1.49E − 21	–	–	–	–	Yes	cis	Low	Gain
rs715	CPS1	2	211,543,055	C	0.29	−0.0155	5.67E − 09	–	–	–	–-	No	trans	Low	Loss
rs1733860	PODXL	7	131,185,995	A	0.36	0.0160	1.70E − 10	–	–	–	–	No	trans	Low	Gain
rs9657518	RP1L1	8	10,467,589	C	0.34	0.0160	2.89E − 08	–	–	–	–	Yes	trans	Low	Gain
rs4639	NEIL2	8	11,644,751	G	0.41	0.0160	1.03E − 10	–	–	–	–	No	cis	Low	Gain
rs1801253	ADRB1	10	115,805,056	C	0.34	0.0182	9.24E − 11	–	–	–	–	No	cis	Low	Loss
rs3758911	CWF19L2	11	107,197,640	C	0.32	0.0142	4.28E − 08	–	–	–	–	No	cis	Low	Gain
rs7398833	CUX2	12	111,786,892	C	0.24	−0.0201	7.33E −12	−0.0344	1.22E−03	−0.0431	1.78E−05	No	trans	Low	Gain
rs1885986	SMG6	17	2,203,175	G	0.34	−0.0173	2.07E − 11	–	–	–	–	No	cis	Medium	Loss
rs17650901	MAPT	17	44,039,691	G	0.23	−0.0168	9.87E − 09	–	–	–	–	No	cis	Low	Loss
rs1881193	KANSL1	17	44,248,769	C	0.23	−0.0169	8.73E − 09	–	–	–	–	No	trans	Medium	Loss
rs197922	GOSR2	17	45,008,570	A	0.35	0.0166	1.30E − 10	0.0313	9.70E − 04	–	–	Yes	cis	Low	Loss
rs740406	DOT1L	19	2,232,221	G	0.07	0.0295	2.79E − 08	−0.0381	3.03E − 02	–	–	Yes	cis	Low	Gain

m⁶A-SNP N⁶-methyladenosine-associated single-nucleotide polymorphisms, GWAS genome-wide association studies, CAD coronary artery disease, CHR chromosome, DBP diastolic blood pressure, EA effect allele, EAF effect allele frequency, eQTL expression quantitative locus, SBP systolic blood pressure, SE standard error, SNP single-nucleotide polymorphism
^aAssembly: GRCh37.p13
^bWhether the BP association has been replicated in East Asians
^cThe effect alleles may result in loss or gain of m⁶A sites

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