Table 3 The significant m6A -SNPs for DBP in GWAS-2018
SNP rsID | Gene | CHR | Positiona | EA | EAF | GWAS | eQTL effect | Confidence level | m6A functionc | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
β DBP | P DBP | β CAD | P CAD | β stroke | P stroke | Asianb | |||||||||
rs56001051 | C1orf167 | 1 | 11,838,841 | G | 0.10 | −0.0354 | 4.50E − 19 | − | − | − | − | Yes | cis | Low | Gain |
rs8024 | IPO9 | 1 | 201,845,575 | A | 0.32 | 0.0166 | 1.62E − 10 | 0.0416 | 3.60E − 05 | 0.0258 | 7.03E − 03 | No | cis | High | Loss |
rs2275155 | SDCCAG8 | 1 | 243,493,907 | T | 0.33 | 0.0257 | 1.06E − 21 | − | − | − | − | No | cis | Low | Loss |
rs9847953 | ZNF589 | 3 | 48,282,695 | G | 0.23 | −0.0152 | 7.59E −09 | −0.0317 | 1.99E −03 | − | − | No | cis | Low | Loss |
rs1353776 | AMOTL2 | 3 | 134,077,470 | G | 0.39 | −0.0142 | 3.14E − 08 | − | − | −0.0267 | 7.95E − 03 | No | trans | Low | Gain |
rs3757138 | BTN3A2 | 6 | 26,376,103 | G | 0.11 | −0.0199 | 3.49E − 08 | − | − | − | − | No | cis | High | Loss |
rs1978 | BTN3A2 | 6 | 26,377,573 | A | 0.11 | −0.0200 | 3.10E − 08 | − | − | − | − | No | cis | Low | Gain |
rs853678 | ZSCAN31 | 6 | 28,297,313 | A | 0.11 | −0.0188 | 1.48E − 08 | − | − | 0.0258 | 3.04E − 02 | Yes | cis | Medium | Loss |
rs2232423 | ZSCAN12 | 6 | 28,366,151 | G | 0.08 | −0.0243 | 2.26E − 10 | − | − | − | − | No | trans | Medium | Loss |
rs450630 | SCAND3 | 6 | 28,542,424 | A | 0.42 | −0.0151 | 9.56E − 10 | − | − | − | − | No | cis | Medium | Loss |
rs9262143 | PPP1R18 | 6 | 30,652,781 | T | 0.09 | −0.0207 | 2.63E − 09 | − | − | − | − | No | cis | Low | Gain |
rs1049633 | DDR1 | 6 | 30,867,527 | A | 0.09 | −0.0211 | 8.35E − 10 | − | − | − | − | No | trans | Medium | Loss |
rs2233974 | C6orf15 | 6 | 31,080,016 | G | 0.15 | −0.0195 | 2.96E − 10 | − | − | − | − | No | trans | Low | Gain |
rs707908 | HLA-C | 6 | 31,238,053 | C | 0.39 | 0.0209 | 3.80E − 16 | − | − | − | − | No | cis | Low | Loss |
rs3115672 | MSH5 | 6 | 31,727,897 | T | 0.08 | −0.0254 | 1.94E −12 | − | − | − | − | No | trans | Low | Gain |
rs4993986 | HLA-DQB1 | 6 | 32,627,652 | G | 0.50 | 0.0152 | 3.45E −09 | − | − | − | − | No | trans | High | Loss |
rs564449 | EPO | 7 | 100,321,138 | G | 0.11 | −0.0240 | 3.61E − 10 | −0.0387 | 9.45E − 03 | − | − | No | trans | Low | Gain |
rs1733860 | PODXL | 7 | 131,185,995 | A | 0.36 | 0.0141 | 1.94E − 08 | − | − | − | − | No | trans | Low | Gain |
rs2979247 | ERI1 | 8 | 8,888,948 | G | 0.41 | 0.0173 | 4.41E − 12 | − | − | − | − | No | cis | Low | Loss |
rs4639 | NEIL2 | 8 | 11,644,751 | G | 0.41 | 0.0177 | 9.98E − 13 | − | − | − | − | No | cis | Low | Gain |
rs1801253 | ADRB1 | 10 | 115,805,056 | C | 0.34 | 0.0242 | 6.04E − 18 | − | − | − | − | No | cis | Low | Loss |
rs7398833 | CUX2 | 12 | 111,786,892 | C | 0.24 | −0.0257 | 2.00E −18 | −0.0344 | 1.22E −03 | −0.0431 | 1.78E − 05 | No | trans | Low | Gain |
rs12828755 | PITPNM2 | 12 | 123,470,586 | T | 0.22 | −0.0201 | 7.00E − 11 | − | − | −0.0299 | 1.14E − 02 | No | cis | Low | Gain |
rs72681869 | SOS2 | 14 | 50,655,357 | C | 0.01 | −0.0779 | 4.97E − 11 | − | − | − | −- | No | trans | Low | Gain |
rs1885986 | SMG6 | 17 | 2,203,175 | G | 0.34 | −0.0155 | 2.06E −09 | − | − | − | − | No | cis | Medium | Gain |
rs6066802 | PREX1 | 20 | 47,261,017 | C | 0.26 | −0.0157 | 2.04E − 08 | 0.0293 | 3.61E − 03 | − | − | No | cis | Low | Gain |
