Table 3 Joint effect of hypertension, diabetes, and smoking on moderate to severe SVD score (≥2)
Factor 1 | Factor 2 | None to mild group (SVD score <2) | Moderate to severe group (SVD score ≥2) | |
|---|---|---|---|---|
n | n | Adjusted OR (95% CI) | ||
Hypertension | Current smoking | |||
(−) | (−) | 463 | 17 | 1.00 (ref.) |
(−) | (+) | 68 | 3 | 1.14a (0.30–4.30) |
(+) | (−) | 221 | 43 | 3.24a (1.75–6.02) |
(+) | (+) | 32 | 11 | 10.59a (3.97–28.3) |
Synergy index | 4.03a (1.17–13.8) | |||
Hypertension | Diabetes | |||
(−) | (−) | 501 | 17 | 1.00 (ref.) |
(−) | (+) | 30 | 3 | 2.27b (0.60–8.58) |
(+) | (−) | 229 | 42 | 3.72b (2.02–6.86) |
(+) | (+) | 24 | 12 | 9.48b (3.80–23.66) |
Synergy index | 2.12b (0.68–6.67) | |||
Hypertension | BMI ≥ 25 | |||
(−) | (−) | 435 | 14 | 1.00 (ref.) |
(−) | (+) | 96 | 6 | 1.96c (0.72–5.35) |
(+) | (−) | 163 | 37 | 4.69c (2.42–9.10) |
(+) | (+) | 90 | 17 | 4.57c (2.12–9.86) |
Synergy index | 0.77c (0.32–1.84) | |||
Diabetes | Current smoking | |||
(−) | (−) | 642 | 48 | 1.00 (ref.) |
(−) | (+) | 88 | 11 | 2.14d (0.95–4.84) |
(+) | (−) | 42 | 12 | 2.88d (1.31–6.30) |
(+) | (+) | 12 | 3 | 3.99d (0.97–16.39) |
Synergy index | 0.99d (0.14–7.02) | |||
Diabetes | BMI ≥ 25 | |||
(−) | (−) | 567 | 41 | 1.00 (ref.) |
(−) | (+) | 163 | 18 | 1.31e (0.70–2.44) |
(+) | (−) | 31 | 10 | 3.06e (1.28–7.31) |
(+) | (+) | 23 | 5 | 2.07e (0.68–6.36) |
Synergy index | 0.45e (0.05–4.54) | |||
Current smoking | BMI ≥ 25 | |||
(−) | (−) | 531 | 40 | 1.00 (ref.) |
(−) | (+) | 153 | 20 | 1.22f (0.66–2.28) |
(+) | (−) | 67 | 11 | 2.46f (1.07–5.64) |
(+) | (+) | 33 | 3 | 2.14f (0.55–8.31) |
Synergy index | 0.68f (0.05–9.07) | |||
