Fig. 6
From: Effects of empagliflozin on nondiabetic salt-sensitive hypertension in uninephrectomized rats
Quantitative polymerase chain reaction (qPCR) data for mRNA levels of inflammatory mediators and oxidative stress-related biomarkers. qPCR results for the inflammatory mediators and oxidative stress-related biomarkers are shown. GAPDH was used as an internal standard, and the relative amounts of target-mRNA are expressed as a percentage of the GAPDH mRNA level. NLRP3, NOD-like receptor family, pyrin domain-containing 3; caspase-1, interleukin 1β-converting enzyme (ICE); ASC, apoptosis-associated speck-like protein containing a caspase activation and recruitment domain; IL, interleukin; MCP1, monocyte chemotactic protein-1; RANTES, regulated on activation, normal T-cell expressed and secreted; NOX, nicotinamide adenine dinucleotide phosphate oxidase; CuZn-SOD, intracellular superoxide dismutase; Mn-SOD, mitochondrial SOD. SCs, sham controls (n = 4); UCs, uninephrectomized controls (n = 4); ETs, empagliflozin-treated rats (n = 5). *P < 0.05 vs. SCs; #P < 0.05 vs. UCs by the Mann–Whitney U test
