Fig. 3

Impact of luseogliflozin treatment on MAP circadian rhythm. Average 12-h MAP in the inactive and active periods (a) during NSD feeding, (b) after 5 days on a HSD, and (c) 2 days after switching to a NSD. *P < 0.05, **P < 0.01, ***P < 0.001 vs. the inactive period of the respective group. d Differences in 12-h MAP between the inactive and active periods in adenine-induced CKD rats with or without luseogliflozin treatment. *P < 0.05, **P < 0.01 vs. vehicle group