Fig. 3

Cost-effectiveness plot. Each dot represents one Monte Carlo simulation result of incremental QALY and cost. The green plots indicate that the simulation outputs demonstrated that DTx + TAU was cost-effective in terms of ICER less than ¥5 million/QALY gained, whereas the red plots denote that the outputs did not show that DTx + TAU was cost-effective or that ICER exceeded the threshold value. The green ellipse indicates the 95% confidence area of the simulations. The probability rates of dominance (the area filled with light blue) and cost-effectiveness (the area filled with light green) were 6.5% and 81.3%, respectively. Abbreviations: ICER incremental cost-effectiveness ratio, JPY Japanese yen, QALY quality-adjusted life years, WTP willingness-to-pay