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Update on Hypertension Research in 2021

Hypertension Research volume 45, pages 1276–1297 (2022)Cite this article

Abstract

In 2021, 217 excellent manuscripts were published in Hypertension Research. Editorial teams greatly appreciate the authors’ contribution to hypertension research progress. Here, our editorial members have summarized twelve topics from published work and discussed current topics in depth. We hope you enjoy our special feature, “Update on Hypertension Research in 2021”.

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References

  1. Higashi Y, Noma K, Yoshizumi M, Kihara Y. Endothelial function and oxidative stress in cardiovascular diseases. Circ J. 2009;73:411–8.

    Article  CAS  PubMed  Google Scholar 

  2. Maruhashi T, Kihara Y, Higashi Y. Assessment of endothelium-independent vasodilation: from methodology to clinical perspectives. J Hypertens. 2018;36:1460–7.

    Article  CAS  PubMed  Google Scholar 

  3. Ohkuma T, Ninomiya T, Tomiyama H, Kario K, Hoshide S, Kita Y, et al. Brachial-ankle pulse wave velocity and the risk prediction of cardiovascular disease: an individual participant data meta-analysis. Hypertension 2017;69:1045–52.

    Article  CAS  PubMed  Google Scholar 

  4. Polak JF, Pencina MJ, Pencina KM, O’Donnell CJ, Wolf PA, D’Agostino RB Sr. Carotid-wall intima-media thickness and cardiovascular events. N Engl J Med. 2011;365:213–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Tanaka A, Tomiyama H, Maruhashi T, Matsuzawa Y, Miyoshi T, Kabutoya T, et al. Physiological diagnostic criteria for vascular failure. Hypertension. 2018;72:1060–71.

    Article  CAS  PubMed  Google Scholar 

  6. Ankle Brachial Index C, Fowkes FG, Murray GD, Butcher I, Heald CL, Lee RJ, et al. Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis. JAMA. 2008;300:197–208.

    Article  Google Scholar 

  7. Potier L, Halbron M, Bouilloud F, Dadon M, Le Doeuff J, Ha Van G, et al. Ankle-to-brachial ratio index underestimates the prevalence of peripheral occlusive disease in diabetic patients at high risk for arterial disease. Diabetes Care. 2009;32:e44.

    Article  PubMed  Google Scholar 

  8. Maruhashi T, Kajikawa M, Kishimoto S, Hashimoto H, Takaeko Y, Yamaji T, et al. Upstroke time is a useful vascular marker for detecting patients with coronary artery disease among subjects with normal Ankle-Brachial Index. J Am Heart Assoc. 2020;9:e017139.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Maruhashi T, Matsui S, Yusoff FM, Kishimoto S, Kajikawa M, Higashi Y. Falsely normalized ankle-brachial index despite the presence of lower-extremity peripheral artery disease: two case reports. J Med Case Rep. 2021;15:622.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Tsai WC, Lee WH, Chen YC, Liu YH, Chang CT, Hsu PC, et al. Combination of low ankle-brachial index and high ankle-brachial index difference for mortality prediction. Hypertens Res. 2021;44:850–7.

    Article  PubMed  Google Scholar 

  11. Sang T, Lv N, Dang A, Cheng N, Zhang W. Brachial-ankle pulse wave velocity and prognosis in patients with atherosclerotic cardiovascular disease: a systematic review and meta-analysis. Hypertens Res. 2021;44:1175–85.

    Article  PubMed  Google Scholar 

  12. Harada T, Kajikawa M, Maruhashi T, Kishimoto S, Yamaji T, Han Y, et al. Short stature is associated with low flow-mediated vasodilation in Japanese men. Hypertens Res. 2022;45:308–14.

    Article  CAS  PubMed  Google Scholar 

  13. Paajanen TA, Oksala NK, Kuukasjarvi P, Karhunen PJ. Short stature is associated with coronary heart disease: a systematic review of the literature and a meta-analysis. Eur Heart J. 2010;31:1802–9.

    Article  PubMed  Google Scholar 

  14. Miyaoka Y, Okada T, Tomiyama H, Morikawa A, Rinno S, Kato M, et al. Structural changes in renal arterioles are closely associated with central hemodynamic parameters in patients with renal disease. Hypertens Res. 2021;44:1113–21.

    Article  CAS  PubMed  Google Scholar 

  15. Yamaji T, Harada T, Hashimoto Y, Nakano Y, Kajikawa M, Yoshimura K, et al. Stair climbing activity and vascular function in patients with hypertension. Hypertens Res. 2021;44:1274–82.

    Article  CAS  PubMed  Google Scholar 

  16. Funakoshi S, Satoh A, Maeda T, Kawazoe M, Ishida S, Yoshimura C, et al. Eating before bed and new-onset hypertension in a Japanese population: the Iki city epidemiological study of atherosclerosis and chronic kidney disease. Hypertens Res. 2021;44:1662–7.

    Article  PubMed  Google Scholar 

  17. Anuwatmatee S, Tang S, Wu BJ, Rye KA, Ong KL. Fibroblast growth factor 21 in chronic kidney disease. Clin Chim Acta. 2019;489:196–202.

    Article  CAS  PubMed  Google Scholar 

  18. Kohara M, Masuda T, Shiizaki K, Akimoto T, Watanabe Y, Honma S, et al. Association between circulating fibroblast growth factor 21 and mortality in end-stage renal disease. PLoS One. 2017;12:e0178971.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  19. Matsui M, Kosaki K, Kuro OM, Saito C, Yamagata K, Maeda S. Circulating fibroblast growth factor 21 links hemodynamics with kidney function in middle-aged and older adults: a mediation analysis. Hypertens Res. 2022;45:125–34.

    Article  CAS  PubMed  Google Scholar 

  20. Lenihan CR, Busque S, Derby G, Blouch K, Myers BD, Tan JC. The association of predonation hypertension with glomerular function and number in older living kidney donors. J Am Soc Nephrol. 2015;26:1261–7.

    Article  PubMed  Google Scholar 

  21. Tsuboi N, Sasaki T, Okabayashi Y, Haruhara K, Kanzaki G, Yokoo T. Assessment of nephron number and single-nephron glomerular filtration rate in a clinical setting. Hypertens Res. 2021;44:605–17.

    Article  PubMed  Google Scholar 

  22. Heerspink HJL, Stefansson BV, Correa-Rotter R, Chertow GM, Greene T, Hou FF, et al. Dapagliflozin in patients with chronic kidney disease. N Engl J Med. 2020;383:1436–46.

    Article  CAS  PubMed  Google Scholar 

  23. Packer M, Anker SD, Butler J, Filippatos G, Pocock SJ, Carson P, et al. Cardiovascular and renal outcomes with empagliflozin in heart failure. N Engl J Med. 2020;383:1413–24.

    Article  CAS  PubMed  Google Scholar 

  24. Nagasu H, Yano Y, Kanegae H, Heerspink HJL, Nangaku M, Hirakawa Y, et al. Kidney outcomes associated with SGLT2 inhibitors versus other glucose-lowering drugs in real-world clinical practice: the Japan chronic kidney disease database. Diabetes Care. 2021;44:2542–51.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Thomson SC, Vallon V. Effects of SGLT2 inhibitor and dietary NaCl on glomerular hemodynamics assessed by micropuncture in diabetic rats. Am J Physiol Ren Physiol. 2021;320:F761–F71.

    Article  CAS  Google Scholar 

  26. Kario K, Ferdinand KC, O’Keefe JH. Control of 24-hour blood pressure with SGLT2 inhibitors to prevent cardiovascular disease. Prog Cardiovasc Dis. 2020;63:249–62.

    Article  PubMed  Google Scholar 

  27. Masuda T, Nagata D. Recent advances in the management of secondary hypertension: chronic kidney disease. Hypertens Res. 2020;43:869–75.

    Article  PubMed  Google Scholar 

  28. Kravtsova O, Bohovyk R, Levchenko V, Palygin O, Klemens CA, Rieg T, et al. SGLT2 inhibition effect on salt-induced hypertension, RAAS, and sodium transport in Dahl SS rats. Am J Physiol Renal Physiol. 2022. https://doi.org/10.1152/ajprenal.00053.2022.

  29. Bohm M, Anker SD, Butler J, Filippatos G, Ferreira JP, Pocock SJ, et al. Empagliflozin improves cardiovascular and renal outcomes in heart failure irrespective of systolic blood pressure. J Am Coll Cardiol. 2021;78:1337–48.

    Article  PubMed  CAS  Google Scholar 

  30. Ohara K, Masuda T, Murakami T, Imai T, Yoshizawa H, Nakagawa S, et al. Effects of the sodium-glucose cotransporter 2 inhibitor dapagliflozin on fluid distribution: A comparison study with furosemide and tolvaptan. Nephrology. 2019;24:904–11.

    CAS  PubMed  Google Scholar 

  31. Masuda T, Watanabe Y, Fukuda K, Watanabe M, Onishi A, Ohara K, et al. Unmasking a sustained negative effect of SGLT2 inhibition on body fluid volume in the rat. Am J Physiol Ren Physiol. 2018;315:F653–F64.

    Article  CAS  Google Scholar 

  32. Ohara K, Masuda T, Morinari M, Okada M, Miki A, Nakagawa S, et al. The extracellular volume status predicts body fluid response to SGLT2 inhibitor dapagliflozin in diabetic kidney disease. Diabetol Metab Syndr. 2020;12:37.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Masuda T, Muto S, Fukuda K, Watanabe M, Ohara K, Koepsell H, et al. Osmotic diuresis by SGLT2 inhibition stimulates vasopressin-induced water reabsorption to maintain body fluid volume. Physiol Rep. 2020;8:e14360.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Eickhoff MK, Dekkers CCJ, Kramers BJ, Laverman GD, Frimodt-Moller M, Jorgensen NR, et al. Effects of dapagliflozin on volume status when added to renin-angiotensin system inhibitors. J Clin Med. 2019;8:779.

  35. Sen T, Scholtes R, Greasley PJ, Cherney D, Dekkers CCJ, Vervloet M, et al. Effects of dapagliflozin on volume status and systemic hemodynamics in patients with CKD without diabetes: results from DAPASALT and DIAMOND. Diabetes Obes Metab. 2022. https://doi.org/10.1111/dom.14729.

  36. Scholtes RA, Muskiet MHA, van Baar MJB, Hesp AC, Greasley PJ, Karlsson C, et al. Natriuretic effect of two weeks of dapagliflozin treatment in patients with type 2 diabetes and preserved kidney function during standardized sodium intake: results of the DAPASALT trial. Diabetes Care. 2021;44:440–7.

    Article  CAS  PubMed  Google Scholar 

  37. Zanchi A, Pruijm M, Muller ME, Ghajarzadeh-Wurzner A, Maillard M, Dufour N, et al. Twenty-four hour blood pressure response to empagliflozin and its determinants in normotensive non-diabetic subjects. Front Cardiovasc Med. 2022;9:854230.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Chilton R, Tikkanen I, Cannon CP, Crowe S, Woerle HJ, Broedl UC, et al. Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes. Diabetes Obes Metab. 2015;17:1180–93.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Cherney DZ, Perkins BA, Soleymanlou N, Har R, Fagan N, Johansen OE, et al. The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus. Cardiovasc Diabetol. 2014;13:28.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  40. Nagai M, Forster CY, Dote K, Shimokawa H. Sex hormones in heart failure revisited? Eur J Heart Fail. 2019;21:308–10.

    Article  PubMed  Google Scholar 

  41. Takami T, Hoshide S, Kario K. Differential impact of antihypertensive drugs on cardiovascular remodeling: a review of findings and perspectives for HFpEF prevention. Hypertens Res. 2022;45:53–60.

    Article  PubMed  Google Scholar 

  42. Wu Y, Quan C, Yang Y, Liang Z, Jiang W, Li X. Renalase improves pressure overload-induced heart failure in rats by regulating extracellular signal-regulated protein kinase 1/2 signaling. Hypertens Res. 2021;44:481–8.

    Article  CAS  PubMed  Google Scholar 

  43. Grabowski K, Herlan L, Witten A, Qadri F, Eisenreich A, Lindner D, et al. Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension. Hypertens Res. 2022;45:292–307.

    Article  CAS  PubMed  Google Scholar 

  44. McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Bohm M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42:3599–726.

    Article  CAS  PubMed  Google Scholar 

  45. Balint B, Jaremek V, Thorburn V, Whitehead SN, Sposato LA. Left atrial microvascular endothelial dysfunction, myocardial inflammation and fibrosis after selective insular cortex ischemic stroke. Int J Cardiol. 2019;292:148–55.

    Article  PubMed  Google Scholar 

  46. Nagai M, Dote K, Kato M. Left atrial fibrosis after ischemic stroke: How the insular cortex-ganglionated plexi axis interacts? Int J Cardiol. 2019;294:16.

    Article  PubMed  Google Scholar 

  47. Kamel H, Rahman AF, O’Neal WT, Lewis CE, Soliman EZ. Effect of intensive blood pressure lowering on left atrial remodeling in the SPRINT. Hypertens Res. 2021;44:1326–31.

    Article  PubMed  Google Scholar 

  48. Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2015;16:233–70.

    Article  PubMed  Google Scholar 

  49. Airale L, Paini A, Ianniello E, Mancusi C, Moreo A, Vaudo G, et al. Left atrial volume indexed for height(2) is a new sensitive marker for subclinical cardiac organ damage in female hypertensive patients. Hypertens Res. 2021;44:692–9.

    Article  CAS  PubMed  Google Scholar 

  50. Inciardi RM, Claggett B, Minamisawa M, Shin SH, Selvaraj S, Goncalves A, et al. Association of left atrial structure and function with heart failure in older adults. J Am Coll Cardiol. 2022;79:1549–61.

    Article  PubMed  Google Scholar 

  51. Kario K, Sun N, Chiang FT, Supasyndh O, Baek SH, Inubushi-Molessa A, et al. Efficacy and safety of LCZ696, a first-in-class angiotensin receptor neprilysin inhibitor, in Asian patients with hypertension: a randomized, double-blind, placebo-controlled study. Hypertension. 2014;63:698–705.

    Article  CAS  PubMed  Google Scholar 

  52. Jackson AM, Jhund PS, Anand IS, Dungen HD, Lam CSP, Lefkowitz MP, et al. Sacubitril-valsartan as a treatment for apparent resistant hypertension in patients with heart failure and preserved ejection fraction. Eur Heart J. 2021;42:3741–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Suzuki K, Claggett B, Minamisawa M, Nochioka K, Mitchell GF, Anand IS, et al. Pulse pressure, prognosis, and influence of sacubitril/valsartan in heart failure with preserved ejection fraction. Hypertension. 2021;77:546–56.

    Article  CAS  PubMed  Google Scholar 

  54. Kario K, Okada K, Kato M, Nishizawa M, Yoshida T, Asano T, et al. 24-hour blood pressure-lowering effect of an SGLT-2 inhibitor in patients with diabetes and uncontrolled nocturnal hypertension: results from the randomized, placebo-controlled SACRA study. Circulation. 2018. https://doi.org/10.1161/CIRCULATIONAHA.118.037076.

  55. Anker SD, Butler J, Filippatos G, Ferreira JP, Bocchi E, Bohm M, et al. Empagliflozin in heart failure with a preserved ejection fraction. N Engl J Med. 2021;385:1451–61.

    Article  CAS  PubMed  Google Scholar 

  56. Kario K, Williams B. Nocturnal hypertension and heart failure: mechanisms, evidence, and new treatments. Hypertension. 2021;78:564–77.

    Article  CAS  PubMed  Google Scholar 

  57. Kario K, Williams B. Angiotensin receptor-neprilysin inhibitors for hypertension-hemodynamic effects and relevance to hypertensive heart disease. Hypertens Res. 2022. https://doi.org/10.1038/s41440-022-00923-2.

  58. Brown MA, Magee LA, Kenny LC, Karumanchi SA, McCarthy FP, Saito S, et al. Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for international practice. Hypertension. 2018;72:24–43.

    Article  CAS  PubMed  Google Scholar 

  59. Gestational Hypertension and Preeclampsia. ACOG practice bulletin, number 222. Obstet Gynecol. 2020;135:e237–e60.

    Article  Google Scholar 

  60. American College of O, Gynecologists’ Committee on Practice B-O. ACOG Practice Bulletin No. 203: chronic hypertension in pregnancy. Obstet Gynecol. 2019;133:e26–e50.

    Article  Google Scholar 

  61. Suzuki H, Takagi K, Matsubara K, Mito A, Kawasaki K, Nanjo S, et al. Maternal and perinatal outcomes according to blood pressure levels for prehypertension: A review and meta-analysis. Hypertens Res Pregnancy. 2022. https://doi.org/10.14390/jsshp.HRP2021-018.

  62. North RA, McCowan LM, Dekker GA, Poston L, Chan EH, Stewart AW, et al. Clinical risk prediction for pre-eclampsia in nulliparous women: development of model in international prospective cohort. BMJ. 2011;342:d1875.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Zhang J, Klebanoff MA, Roberts JM. Prediction of adverse outcomes by common definitions of hypertension in pregnancy. Obstet Gynecol. 2001;97:261–7.

    CAS  PubMed  Google Scholar 

  64. Ohkuchi A, Masuyama H, Yamamoto T, Kikuchi T, Taguchi N, Wolf C, et al. Economic evaluation of the sFlt-1/PlGF ratio for the short-term prediction of preeclampsia in a Japanese cohort of the PROGNOSIS Asia study. Hypertens Res. 2021;44:822–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. Ohkuchi A, Saito S, Yamamoto T, Minakami H, Masuyama H, Kumasawa K, et al. Short-term prediction of preeclampsia using the sFlt-1/PlGF ratio: a subanalysis of pregnant Japanese women from the PROGNOSIS Asia study. Hypertens Res. 2021;44:813–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Salazar MR, Espeche WG, Leiva Sisnieguez CE, Minetto J, Balbin E, Soria A, et al. Nocturnal hypertension and risk of developing early-onset preeclampsia in high-risk pregnancies. Hypertens Res. 2021;44:1633–40.

    Article  PubMed  Google Scholar 

  67. Ueda A, Hasegawa M, Matsumura N, Sato H, Kosaka K, Abiko K, et al. Lower systolic blood pressure levels in early pregnancy are associated with a decreased risk of early-onset superimposed preeclampsia in women with chronic hypertension: a multicenter retrospective study. Hypertens Res. 2022;45:135–45.

    Article  PubMed  Google Scholar 

  68. Tita AT, Szychowski JM, Boggess K, Dugoff L, Sibai B, Lawrence K, et al. Treatment for mild chronic hypertension during pregnancy. N Engl J Med. 2022;386:1781–92.

    Article  CAS  PubMed  Google Scholar 

  69. Cho L, Davis M, Elgendy I, Epps K, Lindley KJ, Mehta PK, et al. Summary of updated recommendations for primary prevention of cardiovascular disease in women: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020;75:2602–18.

    Article  PubMed  PubMed Central  Google Scholar 

  70. Mendoza M, Garcia-Ruiz I, Maiz N, Rodo C, Garcia-Manau P, Serrano B, et al. Pre-eclampsia-like syndrome induced by severe COVID-19: a prospective observational study. BJOG. 2020;127:1374–80.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  71. Wu J, Deng W, Li S, Yang X. Advances in research on ACE2 as a receptor for 2019-nCoV. Cell Mol Life Sci. 2021;78:531–44.

    Article  CAS  PubMed  Google Scholar 

  72. Giardini V, Carrer A, Casati M, Contro E, Vergani P, Gambacorti-Passerini C. Increased sFLT-1/PlGF ratio in COVID-19: a novel link to angiotensin II-mediated endothelial dysfunction. Am J Hematol. 2020;95:E188–E91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. Kallioinen N, Hill A, Horswill MS, Ward HE, Watson MO. Sources of inaccuracy in the measurement of adult patients’ resting blood pressure in clinical settings: a systematic review. J Hypertens. 2017;35:421–41.

    Article  CAS  PubMed  Google Scholar 

  74. Kario K. Management of hypertension in the digital era. Hypertension, 2020;76:640–50.

    Article  CAS  Google Scholar 

  75. Parati G, Stergiou GS, Bilo G, Kollias A, Pengo M, Ochoa JE, et al. Home blood pressure monitoring: methodology, clinical relevance and practical application: a 2021 position paper by the Working Group on Blood Pressure Monitoring and Cardiovascular Variability of the European Society of Hypertension. J Hypertens. 2021;39:1742–67.

    Article  CAS  PubMed  Google Scholar 

  76. Kario K, Tomitani N, Morimoto T, Kanegae H, Lacy P, Williams B. Relationship between blood pressure repeatedly measured by a wrist-cuff oscillometric wearable blood pressure monitoring device and left ventricular mass index in working hypertensive patients. Hypertens Res. 2022;45:87–96.

    Article  PubMed  Google Scholar 

  77. Roerecke M, Kaczorowski J, Myers MG. Comparing automated office blood pressure readings with other methods of blood pressure measurement for identifying patients with possible hypertension. JAMA Intern Med. 2019;179:351.

    Article  PubMed  PubMed Central  Google Scholar 

  78. Lee EKP, Zhu M, Chan DCC, Yip BHK, McManus R, Wong SYS. Comparative accuracies of automated and manual office blood pressure measurements in a Chinese population. Hypertens Res. 2022;45:324–32.

    Article  PubMed  Google Scholar 

  79. Shimbo D, Artinian NT, Basile JN, Krakoff LR, Margolis KL, Rakotz MK, et al. Self-measured blood pressure monitoring at home: a joint policy statement from the American Heart Association and American Medical Association. Circulation 2020;142:e42–e63.

    Article  PubMed  Google Scholar 

  80. Cohen JB, Lotito MJ, Trivedi UK, Denker MG, Cohen DL, Townsend RR. Cardiovascular events and mortality in white coat hypertension: a systematic review and meta-analysis. Ann Intern Med. 2019;170:853–62.

    Article  PubMed  PubMed Central  Google Scholar 

  81. Bobrie G, Clerson P, Menard J, Postel-Vinay N, Chatellier G, Plouin PF. Masked hypertension: a systematic review. J Hypertens. 2008;26:1715–25.

    Article  CAS  PubMed  Google Scholar 

  82. Uhlig K, Patel K, Ip S, Kitsios GD, Balk EM. Self-measured blood pressure monitoring in the management of hypertension: a systematic review and meta-analysis. Ann Intern Med. 2013;159:185–94.

    Article  PubMed  Google Scholar 

  83. Zhang D, Huang QF, Li Y, Wang JG. A randomized controlled trial on home blood pressure monitoring and quality of care in stage 2 and 3 hypertension. Hypertens Res. 2021;44:533–40.

    Article  CAS  PubMed  Google Scholar 

  84. Hoshide S, Kanegae H, Kario K. Nighttime home blood pressure as a mediator of N-terminal pro-brain natriuretic peptide in cardiovascular events. Hypertens Res. 2021;44:1138–46.

    Article  CAS  PubMed  Google Scholar 

  85. Kario K, Okada K, Kato M, Nishizawa M, Yoshida T, Asano T, et al. Twenty-four-hour blood pressure–lowering effect of a sodium-glucose cotransporter 2 inhibitor in patients with diabetes and uncontrolled nocturnal hypertension. Circulation. 2019;139:2089–97.

    Article  CAS  Google Scholar 

  86. Kario K. The sacubitril/valsartan, a first-in-class, angiotensin receptor neprilysin inhibitor (ARNI): potential uses in hypertension, heart failure, and beyond. Current Cardiol Rep. 2018;20:5.

  87. Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381:752–62.

    Article  PubMed  Google Scholar 

  88. Gupta A, Perdomo S, Billinger S, Beddhu S, Burns J, Gronseth G. Treatment of hypertension reduces cognitive decline in older adults: a systematic review and meta-analysis. BMJ Open. 2020;10:e038971.

    Article  PubMed  PubMed Central  Google Scholar 

  89. Beckett NS, Peters R, Fletcher AE, Staessen JA, Liu L, Dumitrascu D, et al. Treatment of hypertension in patients 80 years of age or older. N Engl J Med. 2008;358:1887–98.

    Article  CAS  PubMed  Google Scholar 

  90. Group SMIftSR, Williamson JD, Pajewski NM, Auchus AP, Bryan RN, Chelune G, et al. Effect of intensive vs standard blood pressure control on probable dementia: a randomized clinical trial. JAMA. 2019;321:553–61.

    Article  Google Scholar 

  91. Streit S, Poortvliet RKE, Gussekloo J. Lower blood pressure during antihypertensive treatment is associated with higher all-cause mortality and accelerated cognitive decline in the oldest-old. Data from the Leiden 85-plus Study. Age Ageing. 2018;47:545–50.

    Article  PubMed  Google Scholar 

  92. Qin J, He Z, Wu L, Wang W, Lin Q, Lin Y, et al. Prevalence of mild cognitive impairment in patients with hypertension: a systematic review and meta-analysis. Hypertens Res. 2021;44:1251–60.

    Article  PubMed  Google Scholar 

  93. Inoue T, Matsuoka M, Shinjo T, Tamashiro M, Oba K, Kakazu M, et al. Blood pressure, frailty status, and all-cause mortality in elderly hypertensives; The Nambu Cohort Study. Hypertens Res. 2022;45:146–54.

    Article  PubMed  Google Scholar 

  94. Benetos A, Petrovic M, Strandberg T. Hypertension management in older and frail older patients. Circ Res. 2019;124:1045–60.

    Article  CAS  PubMed  Google Scholar 

  95. Ishikawa J, Seino S, Kitamura A, Toba A, Toyoshima K, Tamura Y, et al. The relationship between blood pressure and cognitive function. Int J Cardiol Cardiovasc Risk Prev. 2021;10:200104.

    Article  PubMed  PubMed Central  Google Scholar 

  96. Dempsey PC, Larsen RN, Dunstan DW, Owen N, Kingwell BA. Sitting less and moving more: implications for hypertension. Hypertension. 2018;72:1037–46.

    Article  CAS  PubMed  Google Scholar 

  97. Sardeli AV, Griffth GJ, Dos Santos M, Ito MSR, Chacon-Mikahil MPT. The effects of exercise training on hypertensive older adults: an umbrella meta-analysis. Hypertens Res. 2021;44:1434–43.

    Article  PubMed  Google Scholar 

  98. Frattola A, Parati G, Cuspidi C, Albini F, Mancia G. Prognostic value of 24-hour blood pressure variability. J Hypertens. 1993;11:1133–7.

    Article  CAS  PubMed  Google Scholar 

  99. Hanazawa T, Asayama K, Watabe D, Hosaka M, Satoh M, Yasui D, et al. Seasonal variation in self-measured home blood pressure among patients on antihypertensive medications: HOMED-BP study. Hypertens Res. 2017;40:284–90.

    Article  PubMed  Google Scholar 

  100. Hoshide S, Yano Y, Mizuno H, Kanegae H, Kario K. Day-by-day variability of home blood pressure and incident cardiovascular disease in clinical practice: The J-HOP Study (Japan Morning Surge-Home Blood Pressure). Hypertension. 2018;71:177–84.

    Article  CAS  PubMed  Google Scholar 

  101. Johansson JK, Niiranen TJ, Puukka PJ, Jula AM. Prognostic value of the variability in home-measured blood pressure and heart rate: the Finn-Home Study. Hypertension. 2012;59:212–8.

    Article  CAS  PubMed  Google Scholar 

  102. Kario K, Hoshide S, Mizuno H, Kabutoya T, Nishizawa M, Yoshida T, et al. Nighttime blood pressure phenotype and cardiovascular prognosis: practitioner-based nationwide JAMP study. Circulation. 2020;142:1810–20.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  103. Kario K, Pickering TG, Umeda Y, Hoshide S, Hoshide Y, Morinari M, et al. Morning surge in blood pressure as a predictor of silent and clinical cerebrovascular disease in elderly hypertensives: a prospective study. Circulation. 2003;107:1401–6.

    Article  PubMed  Google Scholar 

  104. Muntner P, Whittle J, Lynch AI, Colantonio LD, Simpson LM, Einhorn PT, et al. Visit-to-visit variability of blood pressure and coronary heart disease, stroke, heart failure, and mortality: a cohort study. Ann Intern Med. 2015;163:329–38.

    Article  PubMed  PubMed Central  Google Scholar 

  105. Narita K, Hoshide S, Kario K. Difference between morning and evening home blood pressure and cardiovascular events: the J-HOP Study (Japan Morning Surge-Home Blood Pressure). Hypertens Res. 2021;44:1597–605.

    Article  PubMed  Google Scholar 

  106. Rothwell PM, Howard SC, Dolan E, O’Brien E, Dobson JE, Dahlof B, et al. Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension. Lancet. 2010;375:895–905.

    Article  PubMed  Google Scholar 

  107. de Heus RAA, Tzourio C, Lee EJL, Opozda M, Vincent AD, Anstey KJ, et al. Association between blood pressure variability with dementia and cognitive impairment: a systematic review and meta-analysis. Hypertension. 2021;78:1478–89.

    Article  PubMed  CAS  Google Scholar 

  108. Ishiyama Y, Hoshide S, Kanegae H, Kario K. Increased arterial stiffness amplifies the association between home blood pressure variability and cardiac overload: the J-HOP study. Hypertension. 2020;75:1600–6.

    Article  CAS  PubMed  Google Scholar 

  109. Kokubo A, Kuwabara M, Ota Y, Tomitani N, Yamashita S, Shiga T, et al. Nocturnal blood pressure surge in seconds is a new determinant of left ventricular mass index. J Clin Hypertens. 2022;24:271–82.

    Article  CAS  Google Scholar 

  110. Peters R, Xu Y, Eramudugolla R, Sachdev PS, Cherbuin N, Tully PJ, et al. Diastolic blood pressure variability in later life may be a key risk marker for cognitive decline. Hypertension. 2022;79:1037–44.

    Article  CAS  PubMed  Google Scholar 

  111. Wang Y, Zhao P, Chu C, Du MF, Zhang XY, Zou T, et al. Associations of long-term visit-to-visit blood pressure variability with subclinical kidney damage and albuminuria in adulthood: a 30-year prospective cohort study. Hypertension. 2022. https://doi.org/10.1161/HYPERTENSIONAHA.121.18658):101161HYPERTENSIONAHA12118658.

  112. Kario K, Chirinos JA, Townsend RR, Weber MA, Scuteri A, Avolio A, et al. Systemic hemodynamic atherothrombotic syndrome (SHATS) - Coupling vascular disease and blood pressure variability: Proposed concept from pulse of Asia. Prog Cardiovasc Dis. 2020;63:22–32.

    Article  PubMed  Google Scholar 

  113. Kario K, Tomitani N, Kanegae H, Yasui N, Nishizawa M, Fujiwara T, et al. Development of a new ICT-based multisensor blood pressure monitoring system for use in hemodynamic biomarker-initiated anticipation medicine for cardiovascular disease: the National IMPACT Program Project. Prog Cardiovasc Dis. 2017;60:435–49.

    Article  PubMed  Google Scholar 

  114. Huang JF, Zhang DY, Sheng CS, An DW, Li M, Cheng YB, et al. Isolated nocturnal hypertension in relation to host and environmental factors and clock genes. J Clin Hypertens. 2022. In press.

  115. Ewen S, Dorr O, Ukena C, Linz D, Cremers B, Laufs U, et al. Blood pressure variability after catheter-based renal sympathetic denervation in patients with resistant hypertension. J Hypertens. 2015;33:2512–8.

    Article  CAS  PubMed  Google Scholar 

  116. Hoshide S, Yoshida T, Mizuno H, Aoki H, Tomitani N, Kario K. Association of night-to-night adherence of continuous positive airway pressure with day-to-day morning home blood pressure and its seasonal variation in obstructive sleep apnea. J Am Heart Assoc. 2022;11:e024865.

    Article  PubMed  PubMed Central  Google Scholar 

  117. Narita K, Hoshide S, Kario K. Seasonal variation in blood pressure: current evidence and recommendations for hypertension management. Hypertens Res. 2021;44:1363–72.

    Article  PubMed  Google Scholar 

  118. Umishio W, Ikaga T, Kario K, Fujino Y, Hoshi T, Ando S, et al. Cross-sectional analysis of the relationship between home blood pressure and indoor temperature in winter: a nationwide smart wellness housing survey in Japan. Hypertension. 2019;74:756–66.

    Article  CAS  PubMed  Google Scholar 

  119. Marx N, Davies MJ, Grant PJ, Mathieu C, Petrie JR, Cosentino F, et al. Guideline recommendations and the positioning of newer drugs in type 2 diabetes care. Lancet Diabetes Endocrinol. 2021;9:46–52.

    Article  CAS  PubMed  Google Scholar 

  120. Draznin B, Aroda VR, Bakris G, Benson G, Brown FM, Freeman R.American Diabetes Association Professional Practice Committee et al. 9. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes-2022. Diabetes Care. 2022;45:S125–S43.

    Article  PubMed  Google Scholar 

  121. Tanaka A, Node K. Hypertension in diabetes care: emerging roles of recent hypoglycemic agents. Hypertens Res. 2021;44:897–905.

    Article  PubMed  Google Scholar 

  122. Umemura S, Arima H, Arima S, Asayama K, Dohi Y, Hirooka Y, et al. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019). Hypertens Res. 2019;42:1235–481.

    Article  PubMed  Google Scholar 

  123. Bangalore S, Kumar S, Lobach I, Messerli FH. Blood pressure targets in subjects with type 2 diabetes mellitus/impaired fasting glucose: observations from traditional and bayesian random-effects meta-analyses of randomized trials. Circulation. 2011;123:2799–810.

    Article  CAS  PubMed  Google Scholar 

  124. Reboldi G, Gentile G, Angeli F, Ambrosio G, Mancia G, Verdecchia P. Effects of intensive blood pressure reduction on myocardial infarction and stroke in diabetes: a meta-analysis in 73,913 patients. J Hypertens. 2011;29:1253–69.

    Article  CAS  PubMed  Google Scholar 

  125. Ueki K, Sasako T, Okazaki Y, Kato M, Okahata S, Katsuyama H, et al. Effect of an intensified multifactorial intervention on cardiovascular outcomes and mortality in type 2 diabetes (J-DOIT3): an open-label, randomised controlled trial. Lancet Diabetes Endocrinol. 2017;5:951–64.

    Article  PubMed  Google Scholar 

  126. Cosentino F, Grant PJ, Aboyans V, Bailey CJ, Ceriello A, Delgado V, et al. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur Heart J. 2020;41:255–323.

    Article  PubMed  Google Scholar 

  127. Itoh H, Komuro I, Takeuchi M, Akasaka T, Daida H, Egashira Y, et al. Intensive treat-to-target statin therapy in high-risk japanese patients with hypercholesterolemia and diabetic retinopathy: report of a randomized study. Diabetes Care. 2018;41:1275–84.

    Article  CAS  PubMed  Google Scholar 

  128. Shinohara K, Ikeda S, Enzan N, Matsushima S, Tohyama T, Funakoshi K, et al. Efficacy of intensive lipid-lowering therapy with statins stratified by blood pressure levels in patients with type 2 diabetes mellitus and retinopathy: Insight from the EMPATHY study. Hypertens Res. 2021;44:1606–16.

    Article  CAS  PubMed  Google Scholar 

  129. Node K, Kishi T, Tanaka A, Itoh H, Rakugi H, Ohya Y, et al. The Japanese Society of Hypertension-Digest of plan for the future. Hypertens Res. 2018;41:989–90.

    Article  PubMed  Google Scholar 

  130. Tanaka M. Improving obesity and blood pressure. Hypertens Res. 2020;43:79–89.

    Article  PubMed  Google Scholar 

  131. Haze T, Hatakeyama M, Komiya S, Kawano R, Ohki Y, Suzuki S, et al. Association of the ratio of visceral-to-subcutaneous fat volume with renal function among patients with primary aldosteronism. Hypertens Res. 2021;44:1341–51.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  132. Murai N, Saito N, Nii S, Nishikawa Y, Suzuki A, Kodama E, et al. Postloading insulinemia is independently associated with arterial stiffness in young Japanese persons. Hypertens Res. 2021;44:1515–23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  133. Burchfiel CM, Sharp DS, Curb JD, Rodriguez BL, Abbott RD, Arakaki R, et al. Hyperinsulinemia and cardiovascular disease in elderly men: the Honolulu Heart Program. Arterioscler Thromb Vasc Biol. 1998;18:450–7.

    Article  CAS  PubMed  Google Scholar 

  134. Packer M. Differential Pathophysiological Mechanisms in Heart Failure With a Reduced or Preserved Ejection Fraction in Diabetes. JACC Heart Fail. 2021;9:535–49.

    Article  PubMed  Google Scholar 

  135. Tanaka A, Toyoda S, Node K. Vascular functional tests and preemptive medicine. Hypertens Res. 2021;44:117–9.

    Article  PubMed  Google Scholar 

  136. Tanaka A, Node K. Better vascular function tests in cardiovascular care: learning from evidence and providing improved diagnostics to the patient. Hypertens Res. 2022;45:538–40.

    Article  PubMed  Google Scholar 

  137. Shibata H, Itoh H. Mineralocorticoid receptor-associated hypertension and its organ damage: clinical relevance for resistant hypertension. Am J Hypertens. 2012;25:514–23.

    Article  CAS  PubMed  Google Scholar 

  138. Kario K, Ito S, Itoh H, Rakugi H, Okuda Y, Yamakawa S. Effect of esaxerenone on nocturnal blood pressure and natriuretic peptide in different dipping phenotypes. Hypertens Res. 2022;45:97–105.

    Article  CAS  PubMed  Google Scholar 

  139. Yoshida Y, Yoshida R, Shibuta K, Ozeki Y, Okamoto M, Gotoh K, et al. Quality of life of primary aldosteronism patients by mineralocorticoid receptor antagonists. J Endocr Soc. 2021;5:bvab020.

    Article  PubMed  PubMed Central  Google Scholar 

  140. Ito S, Kashihara N, Shikata K, Nangaku M, Wada T, Okuda Y, et al. Esaxerenone (CS-3150) in patients with type 2 diabetes and microalbuminuria (ESAX-DN): phase 3 randomized controlled clinical trial. Clin J Am Soc Nephrol. 2020;15:1715–27.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  141. Bakris GL, Agarwal R, Anker SD, Pitt B, Ruilope LM, Rossing P, et al. Effect of finerenone on chronic kidney disease outcomes in type 2 diabetes. N Engl J Med. 2020;383:2219–29.

    Article  CAS  PubMed  Google Scholar 

  142. Pitt B, Filippatos G, Agarwal R, Anker SD, Bakris GL, Rossing P, et al. Cardiovascular events with finerenone in kidney disease and type 2 diabetes. N Engl J Med. 2021;385:2252–63.

    Article  CAS  PubMed  Google Scholar 

  143. Agarwal R, Filippatos G, Pitt B, Anker SD, Rossing P, Joseph A, et al. Cardiovascular and kidney outcomes with finerenone in patients with type 2 diabetes and chronic kidney disease: the FIDELITY pooled analysis. Eur Heart J. 2022;43:474–84.

    Article  PubMed  Google Scholar 

  144. Okazaki-Hada M, Moriya A, Nagao M, Oikawa S, Fukuda I, Sugihara H. Different pathogenesis of glucose intolerance in two subtypes of primary aldosteronism: Aldosterone-producing adenoma and idiopathic hyperaldosteronism. J Diabetes Investig. 2020;11:1511–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  145. Zinman B, Wanner C, Lachin JM, Fitchett D, Bluhmki E, Hantel S, et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med. 2015;373:2117–28.

    Article  CAS  PubMed  Google Scholar 

  146. Wiviott SD, Raz I, Bonaca MP, Mosenzon O, Kato ET, Cahn A, et al. Dapagliflozin and cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2019;380:347–57.

    Article  CAS  PubMed  Google Scholar 

  147. McMurray JJV, Solomon SD, Inzucchi SE, Kober L, Kosiborod MN, Martinez FA, et al. Dapagliflozin in patients with heart failure and reduced ejection fraction. N Engl J Med. 2019;381:1995–2008.

    Article  CAS  PubMed  Google Scholar 

  148. Pitt B, Remme W, Zannad F, Neaton J, Martinez F, Roniker B, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med. 2003;348:1309–21.

    Article  CAS  PubMed  Google Scholar 

  149. Zannad F, McMurray JJ, Krum H, van Veldhuisen DJ, Swedberg K, Shi H, et al. Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med. 2011;364:11–21.

    Article  CAS  PubMed  Google Scholar 

  150. Bouhanick B, Delchier MC, Lagarde S, Boulestreau R, Conil C, Gosse P, et al. Radiofrequency ablation for adenoma in patients with primary aldosteronism and hypertension: ADERADHTA, a pilot study. J Hypertens. 2021;39:759–65.

    Article  CAS  PubMed  Google Scholar 

  151. Cano-Valderrama O, Gonzalez-Nieto J, Abad-Cardiel M, Ochagavia S, Runkle I, Mendez JV, et al. Laparoscopic adrenalectomy vs. radiofrequency ablation for the treatment of primary aldosteronism. A single center retrospective cohort analysis adjusted with propensity score. Surg Endosc. 2022;36:1970–8.

    Article  PubMed  Google Scholar 

  152. Guo RQ, Li YM, Li XG. Comparison of the radiofrequency ablation versus laparoscopic adrenalectomy for aldosterone-producing adenoma: a meta-analysis of perioperative outcomes and safety. Updates Surg. 2021;73:1477–85.

    Article  PubMed  Google Scholar 

  153. Brown JM, Auchus RJ, Honzel B, Luther JM, Yozamp N, Vaidya A. Recalibrating interpretations of aldosterone assays across the physiologic range: immunoassay and liquid chromatography-tandem mass spectrometry measurements under multiple controlled conditions. J Endocr Soc. 2022;6:bvac049.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  154. Nishikawa T, Satoh F, Takashi Y, Yanase T, Itoh H, Kurihara I, et al. Comparison and commutability study between standardized liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) and chemiluminescent enzyme immunoassay for aldosterone measurement in blood. Endocr J. 2022;69:45–54.

    Article  CAS  PubMed  Google Scholar 

  155. Ozeki Y, Tanimura Y, Nagai S, Nomura T, Kinoshita M, Shibuta K, et al. Development of a new chemiluminescent enzyme immunoassay using a two-step sandwich method for measuring aldosterone concentrations. Diagnostics. 2021;11:433.

  156. Teruyama K, Naruse M, Tsuiki M, Kobayashi H. Novel chemiluminescent immunoassay to measure plasma aldosterone and plasma active renin concentrations for the diagnosis of primary aldosteronism. J Hum Hypertens. 2022;36:77–85.

    Article  CAS  PubMed  Google Scholar 

  157. Naruse M, Katabami T, Shibata H, Sone M, Takahashi K, Tanabe A, et al. Japan Endocrine Society clinical practice guideline for the diagnosis and management of primary aldosteronism 2021. Endocr J. 2022;69:327–59.

    Article  PubMed  Google Scholar 

  158. Ozeki Y, Kinoshita M, Miyamoto S, Yoshida Y, Okamoto M, Gotoh K, et al. Re-assessment of the oral salt loading test using a new chemiluminescent enzyme immunoassay based on a two-step sandwich method to measure 24-hour urine aldosterone excretion. Front Endocrinol. 2022;13:859347.

    Article  Google Scholar 

  159. Ochiai-Homma F, Kuribayashi-Okuma E, Tsurutani Y, Ishizawa K, Fujii W, Odajima K, et al. Characterization of pendrin in urinary extracellular vesicles in a rat model of aldosterone excess and in human primary aldosteronism. Hypertens Res. 2021;44:1557–67.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  160. Shibata H. Exosomes and exosomal cargo in urinary extracellular vesicles: novel potential biomarkers for mineralocorticoid-receptor-associated hypertension. Hypertens Res. 2021;44:1668–70.

    Article  CAS  PubMed  Google Scholar 

  161. Azizi M, Sanghvi K, Saxena M, Gosse P, Reilly JP, Levy T, et al. Ultrasound renal denervation for hypertension resistant to a triple medication pill (RADIANCE-HTN TRIO): a randomised, multicentre, single-blind, sham-controlled trial. Lancet. 2021;397:2476–86.

    Article  CAS  PubMed  Google Scholar 

  162. Azizi M, Schmieder RE, Mahfoud F, Weber MA, Daemen J, Davies J, et al. Endovascular ultrasound renal denervation to treat hypertension (RADIANCE-HTN SOLO): a multicentre, international, single-blind, randomised, sham-controlled trial. Lancet. 2018;391:2335–45.

    Article  PubMed  Google Scholar 

  163. Bohm M, Kario K, Kandzari DE, Mahfoud F, Weber MA, Schmieder RE, et al. Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial. Lancet. 2020;395:1444–51.

    Article  PubMed  Google Scholar 

  164. Kandzari DE, Bohm M, Mahfoud F, Townsend RR, Weber MA, Pocock S, et al. Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomised trial. Lancet. 2018;391:2346–55.

    Article  PubMed  Google Scholar 

  165. Osborn JW, Foss JD. Renal nerves and long-term control of arterial pressure. Compr Physiol. 2017;7:263–320.

    Article  PubMed  Google Scholar 

  166. Kario K. Essential manual on perfect 24-hour blood pressure management from morning to nocturnal hypertension: up-to-date for anticipation medicine. Wiley Publishing Japan: Tokyo, Japan, 2018, p. 1–328

  167. Foss JD, Wainford RD, Engeland WC, Fink GD, Osborn JW. A novel method of selective ablation of afferent renal nerves by periaxonal application of capsaicin. Am J Physiol Regul Integr Comp Physiol. 2015;308:R112–22.

    Article  CAS  PubMed  Google Scholar 

  168. Zheng H, Katsurada K, Liu X, Knuepfer MM, Patel KP. Specific afferent renal denervation prevents reduction in neuronal nitric oxide synthase within the paraventricular nucleus in rats with chronic heart failure. Hypertension. 2018;72:667–75.

    Article  CAS  PubMed  Google Scholar 

  169. Katsurada K, Ogoyama Y, Imai Y, Patel KP, Kario K. Renal denervation based on experimental rationale. Hypertens Res. 2021;44:1385–94.

    Article  CAS  PubMed  Google Scholar 

  170. Katsurada K, Shinohara K, Aoki J, Nanto S, Kario K. Renal denervation: basic and clinical evidence. Hypertens Res. 2022;45:198–209.

    Article  PubMed  Google Scholar 

  171. Ogoyama Y, Tada K, Abe M, Nanto S, Shibata H, Mukoyama M, et al. Effects of renal denervation on blood pressures in patients with hypertension: a systematic review and meta-analysis of randomized sham-controlled trials. Hypertens Res. 2022;45:210–20.

    Article  PubMed  Google Scholar 

  172. Bohm M, Mahfoud F, Ukena C, Hoppe UC, Narkiewicz K, Negoita M, et al. First report of the Global SYMPLICITY Registry on the effect of renal artery denervation in patients with uncontrolled hypertension. Hypertension. 2015;65:766–74.

    Article  PubMed  CAS  Google Scholar 

  173. Mahfoud F, Bohm M, Schmieder R, Narkiewicz K, Ewen S, Ruilope L, et al. Effects of renal denervation on kidney function and long-term outcomes: 3-year follow-up from the Global SYMPLICITY Registry. Eur Heart J. 2019;40:3474–82.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  174. Kim BK, Bohm M, Mahfoud F, Mancia G, Park S, Hong MK, et al. Renal denervation for treatment of uncontrolled hypertension in an Asian population: results from the Global SYMPLICITY Registry in South Korea (GSR Korea). J Hum Hypertens. 2016;30:315–21.

    Article  CAS  PubMed  Google Scholar 

  175. Mahfoud F, Kandzari DE, Kario K, Townsend RR, Weber MA, Schmieder RE, et al. Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial. Lancet. 2022;399:1401–10.

    Article  CAS  PubMed  Google Scholar 

  176. Bhatt DL, Kandzari DE, O’Neill WW, D’Agostino R, Flack JM, Katzen BT, et al. A controlled trial of renal denervation for resistant hypertension. N Engl J Med. 2014;370:1393–401.

    Article  CAS  PubMed  Google Scholar 

  177. Miyajima E, Yamada Y, Yoshida Y, Matsukawa T, Shionoiri H, Tochikubo O, et al. Muscle sympathetic nerve activity in renovascular hypertension and primary aldosteronism. Hypertension. 1991;17:1057–62.

    Article  CAS  PubMed  Google Scholar 

  178. Feig DI, Kang DH, Johnson RJ. Uric acid and cardiovascular risk. N Engl J Med. 2008;359:1811–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  179. Kuwabara M. Hyperuricemia, cardiovascular disease, and hypertension. Pulse. 2016;3:242–52.

    Article  PubMed  PubMed Central  Google Scholar 

  180. Johnson RJ, Bakris GL, Borghi C, Chonchol MB, Feldman D, Lanaspa MA, et al. Hyperuricemia, acute and chronic kidney disease, hypertension, and cardiovascular disease: report of a scientific workshop organized by the national kidney foundation. Am J Kidney Dis. 2018;71:851–65.

    Article  PubMed  PubMed Central  Google Scholar 

  181. Lanaspa MA, Andres-Hernando A, Kuwabara M. Uric acid and hypertension. Hypertens Res. 2020;43:832–4.

    Article  PubMed  Google Scholar 

  182. Doria A, Galecki AT, Spino C, Pop-Busui R, Cherney DZ, Lingvay I, et al. Serum urate lowering with allopurinol and kidney function in type 1 diabetes. N Engl J Med. 2020;382:2493–503.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  183. Badve SV, Pascoe EM, Tiku A, Boudville N, Brown FG, Cass A, et al. Effects of allopurinol on the progression of chronic kidney disease. N Engl J Med. 2020;382:2504–13.

    Article  CAS  PubMed  Google Scholar 

  184. Kimura K, Hosoya T, Uchida S, Inaba M, Makino H, Maruyama S, et al. Febuxostat therapy for patients with stage 3 CKD and asymptomatic hyperuricemia: a randomized trial. Am J Kidney Dis. 2018;72:798–810.

    Article  CAS  PubMed  Google Scholar 

  185. Tanaka A, Taguchi I, Teragawa H, Ishizaka N, Kanzaki Y, Tomiyama H, et al. Febuxostat does not delay progression of carotid atherosclerosis in patients with asymptomatic hyperuricemia: a randomized, controlled trial. PLoS Med. 2020;17:e1003095.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  186. Mackenzie IS, Ford I, Nuki G, Hallas J, Hawkey CJ, Webster J, et al. Long-term cardiovascular safety of febuxostat compared with allopurinol in patients with gout (FAST): a multicentre, prospective, randomised, open-label, non-inferiority trial. Lancet. 2020;396:1745–57.

    Article  CAS  PubMed  Google Scholar 

  187. White WB, Saag KG, Becker MA, Borer JS, Gorelick PB, Whelton A, et al. Cardiovascular safety of febuxostat or allopurinol in patients with gout. N Engl J Med. 2018;378:1200–10.

    Article  CAS  PubMed  Google Scholar 

  188. Mori K, Furuhashi M, Tanaka M, Higashiura Y, Koyama M, Hanawa N, et al. Serum uric acid level is associated with an increase in systolic blood pressure over time in female subjects: Linear mixed-effects model analyses. Hypertens Res. 2022;45:344–53.

    Article  CAS  PubMed  Google Scholar 

  189. Azegami T, Uchida K, Arima F, Sato Y, Awazu M, Inokuchi M, et al. Association of childhood anthropometric measurements and laboratory parameters with high blood pressure in young adults. Hypertens Res. 2021;44:711–9.

    Article  CAS  PubMed  Google Scholar 

  190. Kawasoe S, Kubozono T, Ojima S, Kawabata T, Miyahara H, Tokushige K, et al. J-shaped curve for the association between serum uric acid levels and the prevalence of blood pressure abnormalities. Hypertens Res. 2021;44:1186–93.

    Article  CAS  PubMed  Google Scholar 

  191. Kuwabara M, Hisatome I, Niwa K, Bjornstad P, Roncal-Jimenez CA, Andres-Hernando A, et al. The optimal range of serum uric acid for cardiometabolic diseases: a 5-year japanese cohort study. J Clin Med. 2020;9:942.

  192. Furuhashi M, Higashiura Y, Koyama M, Tanaka M, Murase T, Nakamura T, et al. Independent association of plasma xanthine oxidoreductase activity with hypertension in nondiabetic subjects not using medication. Hypertens Res. 2021;44:1213–20.

    Article  CAS  PubMed  Google Scholar 

  193. Kusunose K, Yoshida H, Tanaka A, Teragawa H, Akasaki Y, Fukumoto Y, et al. Effect of febuxostat on left ventricular diastolic function in patients with asymptomatic hyperuricemia: a sub analysis of the PRIZE Study. Hypertens Res. 2022;45:106–15.

    Article  CAS  PubMed  Google Scholar 

  194. Chen CW, Wu CH, Liou YS, Kuo KL, Chung CH, Lin YT, et al. Roles of cardiovascular autonomic regulation and sleep patterns in high blood pressure induced by mild cold exposure in rats. Hypertens Res. 2021;44:662–73.

    Article  CAS  PubMed  Google Scholar 

  195. Domingos-Souza G, Santos-Almeida FM, Meschiari CA, Ferreira NS, Pereira CA, Pestana-Oliveira N, et al. The ability of baroreflex activation to improve blood pressure and resistance vessel function in spontaneously hypertensive rats is dependent on stimulation parameters. Hypertens Res. 2021;44:932–40.

    Article  CAS  PubMed  Google Scholar 

  196. Hirooka Y. Sympathetic activation in hypertension: importance of the central nervous system. Am J Hypertens. 2020;33:914–26.

    CAS  PubMed  Google Scholar 

  197. Iyonaga T, Shinohara K, Mastuura T, Hirooka Y, Tsutsui H. Brain perivascular macrophages contribute to the development of hypertension in stroke-prone spontaneously hypertensive rats via sympathetic activation. Hypertens Res. 2020;43:99–110.

    Article  CAS  PubMed  Google Scholar 

  198. Kasacka I, Piotrowska Z, Domian N, Acewicz M, Lewandowska A. Canonical Wnt signaling in the kidney in different hypertension models. Hypertens Res. 2021;44:1054–66.

    Article  CAS  PubMed  Google Scholar 

  199. Matsusaka T, Niimura F, Shimizu A, Pastan I, Saito A, Kobori H, et al. Liver angiotensinogen is the primary source of renal angiotensin II. J Am Soc Nephrol. 2012;23:1181–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  200. Matsuyama T, Ohashi N, Aoki T, Ishigaki S, Isobe S, Sato T, et al. Circadian rhythm of the intrarenal renin-angiotensin system is caused by glomerular filtration of liver-derived angiotensinogen depending on glomerular capillary pressure in adriamycin nephropathy rats. Hypertens Res. 2021;44:618–27.

    Article  CAS  PubMed  Google Scholar 

  201. Otsuki T, Fukuda N, Chen L, Ueno T, Otsuki M, Abe M. TWIST1 transcriptionally upregulates complement 3 in glomerular mesangial cells from spontaneously hypertensive rats. Hypertens Res. 2022;45:66–74.

    Article  CAS  PubMed  Google Scholar 

  202. Liu C, Li X, Fu J, Chen K, Liao Q, Wang J, et al. Increased AT1 receptor expression mediates vasoconstriction leading to hypertension in Snx1(-/-) mice. Hypertens Res. 2021;44:906–17.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  203. Liu X, Jiang D, Huang W, Teng P, Zhang H, Wei C, et al. Sirtuin 6 attenuates angiotensin II-induced vascular adventitial aging in rat aortae by suppressing the NF-kappaB pathway. Hypertens Res. 2021;44:770–80.

    Article  CAS  PubMed  Google Scholar 

  204. Wu H, Lam TYC, Shum TF, Tsai TY, Chiou J. Hypotensive effect of captopril on deoxycorticosterone acetate-salt-induced hypertensive rat is associated with gut microbiota alteration. Hypertens Res. 2022;45:270–82.

    Article  CAS  PubMed  Google Scholar 

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  1. Department of Pharmacology, Ehime University Graduate School of Medicine, 454 Shitsukawa, Tohon, Ehime, 791-0295, Japan

    Masaki Mogi

  2. Department of Regenerative Medicine, Division of Radiation Medical Science, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan

    Tatsuya Maruhashi & Yukihito Higashi

  3. Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan

    Yukihito Higashi

  4. Division of Nephrology, Department of Medicine, Jichi Medical University School of Medicine, 3311-1, Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan

    Takahiro Masuda & Daisuke Nagata

  5. Department of Cardiology, Hiroshima City Asa Hospital, 1-2-1 Kameyamaminami Asakita-ku, Hiroshima, 731-0293, Japan

    Michiaki Nagai

  6. Department of Endocrinology and Hypertension, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan

    Kanako Bokuda & Atsuhiro Ichihara

  7. Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, 2-2, Yamada-oka, Suita, Osaka, 565-0871, Japan

    Yoichi Nozato

  8. Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Sakaecho, Itabashi-ku, Tokyo, 173-0015, Japan

    Ayumi Toba

  9. Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, 3311-1, Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan

    Keisuke Narita, Satoshi Hoshide, Kenichi Katsurada & Kazuomi Kario

  10. Department of Cardiovascular Medicine, Saga University, 5-1-1, Nabeshima, Saga, 849-8501, Japan

    Atsushi Tanaka & Koichi Node

  11. Department of Endocrinology, Metabolism, Rheumatology and Nephrology, Faculty of Medicine, Oita University, 1-1, 1-1 Idaigaoka, Hasama-machi, Yufu city, Oita, 879-5593, Japan

    Yuichi Yoshida & Hirotaka Shibata

  12. Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University School of Medicine, 3311-1, Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan

    Kenichi Katsurada

  13. Department of Cardiology, Toranomon Hospital, 2-2-2, Toranomon, Minato-ku, Tokyo, 105-8470, Japan

    Masanari Kuwabara & Takahide Kodama

  14. Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Keisuke Shinohara

Authors
  1. Masaki Mogi
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  2. Tatsuya Maruhashi
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  3. Yukihito Higashi
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  4. Takahiro Masuda
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  5. Daisuke Nagata
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  6. Michiaki Nagai
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  7. Kanako Bokuda
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  8. Atsuhiro Ichihara
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  9. Yoichi Nozato
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  10. Ayumi Toba
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  11. Keisuke Narita
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  12. Satoshi Hoshide
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  13. Atsushi Tanaka
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  14. Koichi Node
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  15. Yuichi Yoshida
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  16. Hirotaka Shibata
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  17. Kenichi Katsurada
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  18. Masanari Kuwabara
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  19. Takahide Kodama
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  20. Keisuke Shinohara
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  21. Kazuomi Kario
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Corresponding author

Correspondence to Masaki Mogi.

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Mogi, M., Maruhashi, T., Higashi, Y. et al. Update on Hypertension Research in 2021. Hypertens Res 45, 1276–1297 (2022). https://doi.org/10.1038/s41440-022-00967-4

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  • DOI: https://doi.org/10.1038/s41440-022-00967-4

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