Table 2 The association of mean hourly systolic blood pressure between 1 and 24 h with outcomes

From: Intravenous nicardipine for Japanese patients with acute intracerebral hemorrhage: an individual participant data analysis

Outcome

N (%)

Crude

Adjusted. Model 1

Adjusted. Model 2

Odds ratioa

95% CIa

P

Odds ratioa

95% CIa

P

Odds ratioa

95% CIa

P

Death or disability

176/495 (35.6%)

1.17

1.00–1.37

0.0507

1.28

1.07–1.52

0.0051

1.25

1.03–1.52

0.0224

    Adding 2 patients without available datab

178/497 (35.8%)

1.17

1.00–1.36

0.0538

1.28

1.08–1.52

0.0050

1.25

1.03–1.52

0.0221

Hematoma expansion

76/486 (15.6%)

1.51

1.22–1.86

0.0001

1.45

1.16–1.81

0.0011

1.49

1.18–1.87

0.0005

    Adding 13 patients with emergent surgeryc

89/499 (17.8%)

1.44

1.18–1.75

0.0003

1.38

1.13–1.68

0.0015

1.40

1.14–1.73

0.0014

Serious adverse events

88/499 (17.6%)

1.07

0.88–1.30

0.5114

1.11

0.90–1.36

0.3418

1.08

0.87–1.34

0.4892

Cardio-renal serious adverse events

7/499 (1.4%)

1.02

0.54–1.92

0.9478

 

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  1. Multivariable analysis is not done for cardio-renal serious adverse events because of a small event number
  2. Model 1: adjusted for sex, age, and study group
  3. Model 2: adjusted for sex, age, study group, baseline systolic blood pressure, baseline National Institutes of Health Stroke Scale score, baseline hematoma volume, lobar hematoma, and onset-to-randomization time
  4. aper 10 mmHg
  5. b2 patients added are regarded as having death or disability
  6. c13 patients added are regarded as having hematoma expansion
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